Drug General Information
Drug ID
DXS9CR
Drug Name
6-{1-[2-(Naphthalen-1-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one
Synonyms
CHEMBL180445
Indication Discovery agent Investigative [1587926]
Formula
C25H26N2O4
Canonical SMILES
O=C1COc2ccc(OC3CCN(CCOc4cccc5ccccc45)CC3)cc2N1
InChI
InChI=1S/C25H26N2O4/c28-25-17-30-24-9-8-20(16-22(24)26-25)31-19-10-12-27(13-11-19)14-15-29-23-7-3-5-18-4-1-2-6-21(18)23/h1-9,16,19H,10-15,17H2,(H,26,28)
InChIKey
HCAWSBHLTGNXKL-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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