Drug Information

Drug General Information
Drug ID
D00ANG
Former ID
DIB014887
Drug Name
Erythropoietin-transfected autologous cell therapy
Synonyms
Epodure; Erythropoietin-transfected autologous cell therapy (Biopump); Erythropoietin-transfected autologous cell therapy (Biopump), Medgenics
Indication Anemia [ICD9: 280-285; ICD10:D50-D64] Phase 1/2 [522139]
Company
Medgenics
Target and Pathway
Target(s) Erythropoietin ligand Target Info Modulator [525362]
KEGG Pathway Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathway Interaction Database HIF-2-alpha transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
WikiPathways EPO Receptor Signaling
Hematopoietic Stem Cell Differentiation
Differentiation Pathway
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 522139ClinicalTrials.gov (NCT00542568) Safety and Efficacy of Sustained Erythropoietin Therapy. U.S. National Institutes of Health.
Ref 525362Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipients. Mol Ther. 2009 Feb;17(2):369-72. doi: 10.1038/mt.2008.270. Epub 2008 Dec 16.

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