Drug Information

Drug General Information
Drug ID
D00KXZ
Former ID
DIB019110
Drug Name
CGP 54626A
Synonyms
CGP-54626; CGP54626
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538653]
Structure
Download
2D MOL
Formula
C18H28Cl2NO3P
InChI
InChI=1S/C18H28Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h7-9,13-14,16,21-22H,2-6,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
InChIKey
JGGVBBYJRQOPPA-BBRMVZONSA-N
PubChem Compound ID
197584
PubChem Substance ID
7978907, 10673800, 11113905, 14928667, 26752064, 33517416, 47883146, 47957340, 79255887, 85788549, 104239356, 113465530, 135650072, 135651143, 143479297, 229019561, 247429554
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Antagonist [534343]
GABAB receptor Target Info Antagonist [526586]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1070).
Ref 526586Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochem Pharmacol. 2003 Apr 1;65(7):1103-13.
Ref 534343Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.

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