Target Information

Target General Infomation
Target ID
T61972
Former ID
TTDI03214
Target Name
GABAB receptor
Target Type
Research
Antagonist 2-hydroxy-saclofen Drug Info [534343]
CGP 46381 Drug Info [525914]
CGP 54626A Drug Info [526586]
CGP 55845 Drug Info [525914]
CGP 62349 Drug Info [526586]
saclofen Drug Info [526586]
[125I]CGP 64213 Drug Info [525702]
[125I]CGP 71872 Drug Info [534343]
[3H]CGP 54626 Drug Info [534792]
[3H]CGP 62349 Drug Info [525610]
Agonist amino-propylphosphinic acid Drug Info [543626]
[3H](R)-(-)-baclofen Drug Info [543626]
Modulator (allosteric modulator) compound 14 Drug Info [532893]
References
Ref 525610Characterisation and partial purification of the GABA(B) receptor from the rat cerebellum using the novel antagonist [3H]CGP 62349. Brain Res Mol Brain Res. 1999 Aug 25;71(2):279-89.
Ref 525702Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit. Mol Pharmacol. 2000 Mar;57(3):419-26.
Ref 525914The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000 Nov;131(6):1050-4.
Ref 526586Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochem Pharmacol. 2003 Apr 1;65(7):1103-13.
Ref 532893Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5(7):742-7.
Ref 534343Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.
Ref 534792GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature. 1998 Dec 17;396(6712):674-9.
Ref 543626(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 242).

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