Drug General Information
Drug ID	D0S5YH
Former ID	DIB020888
Drug Name	saclofen
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538661]
Structure		Download 2D MOL
Formula	C9H12ClNO3S
InChI	InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
InChIKey	JYLNVJYYQQXNEK-UHFFFAOYSA-N
PubChem Compound ID	122150
PubChem Substance ID	3190659, 6317718, 7978530, 10239965, 15122183, 26751661, 29302596, 47513075, 47734113, 50070504, 50071145, 52092379, 57339985, 85083624, 85209931, 85788319, 91590738, 103280636, 104127796, 104415162, 126434985, 128345664, 135076057, 135650976, 137010114, 142796831, 160813327, 162022515, 162093587, 162204513, 163089574, 163374438, 163837910, 164844936, 171578639, 184592327, 204402940, 226675178, 241181593, 249825384, 250208358, 252059222, 252213990, 252316132, 252430556
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Antagonist	[534343]
	GABAB receptor	Target Info	Antagonist	[526586]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538661	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1078).
Ref 526586	Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochem Pharmacol. 2003 Apr 1;65(7):1103-13.
Ref 534343	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.

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