Drug Information

Drug General Information
Drug ID
D0Z9QI
Former ID
DIB019113
Drug Name
CGP 62349
Synonyms
CGP62349; CGP-62349
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538655]
Structure
Download
2D MOL
Formula
C21H28NO6P
InChI
InChI=1S/C21H28NO6P/c1-15(17-5-4-6-18(11-17)21(24)25)22(2)12-19(23)14-29(26,27)13-16-7-9-20(28-3)10-8-16/h4-11,15,19,23H,12-14H2,1-3H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
InChIKey
AKUSEWDIEMJQBM-BEFAXECRSA-N
PubChem Compound ID
5310936
PubChem Substance ID
7978468, 39340684, 51048976, 57359296, 114154884, 135650076, 178100432, 237541221
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Antagonist [534343]
GABAB receptor Target Info Antagonist [526586]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538655(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1072).
Ref 526586Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochem Pharmacol. 2003 Apr 1;65(7):1103-13.
Ref 534343Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46.

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