Drug Information

Drug General Information
Drug ID
D00USF
Former ID
DAP000104
Drug Name
Trazodone
Synonyms
Beneficat; Desirel; Sideril; Tradozone; Trazalon; Trazodil; Trazodon; Trazodona; Trazodonum; Trazolan; Trazonil; Trialodine; Trittico; Desyrel Dividose; Trazodona [Spanish]; Trazodone Hcl; Trazodonum [Latin]; Beneficat (TN); Deprax (TN); Desirel (TN); Desyrel (TN); Desyrel(trazodone hcl salt); Molipaxin (TN); Thombran (TN); Trazodona [INN-Spanish]; Trazodone (Desyrel); Trazodone (INN); Trazodone [INN:BAN]; Trazodonum [INN-Latin]; Trazorel (TN); Trialodine (TN); Trittico (TN); 2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 8-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-1,7,8-triazabicyclo[4.3.0]nona-2,4,6-trien-9-one hydrochloride
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536306], [539351]
Therapeutic Class
Antidepressants
Company
Angelini research laboratories
Structure
Download
2D MOL

3D MOL
Formula
C19H22ClN5O
InChI
InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
InChIKey
PHLBKPHSAVXXEF-UHFFFAOYSA-N
CAS Number
CAS 19794-93-5
PubChem Compound ID
5533
PubChem Substance ID
9365, 5659231, 7980825, 8153406, 11111900, 11111901, 11335371, 11360610, 11364318, 11366880, 11369442, 11372639, 11374249, 11377604, 11461582, 11466320, 11467440, 11484603, 11486179, 11488670, 11491375, 11492570, 11495238, 14828880, 24263015, 29224575, 46506648, 47216661, 47440129, 47515189, 47662138, 47736344, 47959598, 48184872, 48259097, 48259098, 49698420, 50057656, 50100361, 50104290, 56394831, 57322830, 75102958, 85209489, 85788818, 90341328, 92717483, 93619784, 96025310, 103188158
ChEBI ID
ChEBI:9654
SuperDrug ATC ID
N06AX05
SuperDrug CAS ID
cas=019794935
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Modulator [556264]
5-hydroxytryptamine 1A receptor Target Info Modulator [556264]
KEGG Pathway Serotonergic synapsehsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536306Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 539351(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 213).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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