Drug Information

Drug General Information
Drug ID
D00YXU
Former ID
DIB000049
Drug Name
CCX-025
Synonyms
CCX-807; CCR9 chemokine receptor-targeting therapeutic (gastrointestinal diseases), ChemoCentryx
Indication Crohn's disease [ICD9: 555; ICD10:K50] Phase 1 [549896]
Company
ChemoCentryx Inc
Target and Pathway
Target(s) CCR9 chemokine receptor Target Info Antagonist [530993], [532026]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Intestinal immune network for IgA production
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 549896Clinical pipeline report, company report or official report of ChemoCentryx Inc.
Ref 530993GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease. IDrugs. 2010 Jul;13(7):472-81.
Ref 532026Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29.

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