Target Information

Target General Infomation
Target ID
T97873
Former ID
TTDNC00667
Target Name
CCR9 chemokine receptor
Gene Name
CCR9
Synonyms
CC CKR9; CC chemokine receptor type 9; CCCKR9; CDw199; GPR96; Gprotein coupled receptor 28; CCR9
Target Type
Clinical Trial
Disease Crohn's disease [ICD9: 555; ICD10: K50]
Sjogren's syndrome [ICD9: 710.2; ICD10: M35.0]
Function
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
BioChemical Class
GPCR rhodopsin
UniProt ID
P51686
Sequence
MTPTDFTSPIPNMADDYGSESTSSMEDYVNFNFTDFYCEKNNVRQFASHFLPPLYWLVFI
VGALGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLVTLPFWAIAAADQWKFQTFMCK
VVNSMYKMNFYSCVLLIMCISVDRYIAIAQAMRAHTWREKRLLYSKMVCFTIWVLAAALC
IPEILYSQIKEESGIAICTMVYPSDESTKLKSAVLTLKVILGFFLPFVVMACCYTIIIHT
LIQAKKSSKHKALKVTITVLTVFVLSQFPYNCILLVQTIDAYAMFISNCAVSTNIDICFQ
VTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFTRREGSLKLSSMLL
ETTSGALSL
Drugs and Mode of Action
Drug(s) Vercirnon Drug Info Phase 3 Crohn's disease [523801]
CCX-025 Drug Info Phase 1 Crohn's disease [549896]
MLN-3126 Drug Info Phase 1 Sjogren's syndrome [524863]
Antagonist CCX-025 Drug Info [530993], [532026]
MLN-3126 Drug Info [530993], [532026]
Modulator Vercirnon Drug Info [530993]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Intestinal immune network for IgA production
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523801ClinicalTrials.gov (NCT01536418) An Active Treatment Study to Induce Clinical Response and/or Remission With GSK1605786A in Subjects With Crohn's Disease. U.S. National Institutes of Health.
Ref 524863ClinicalTrials.gov (NCT02209506) Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MLN3126 in Healthy Japanese and Non-Japanese Participants. U.S. National Institutes of Health.
Ref 549896Clinical pipeline report, company report or official report of ChemoCentryx Inc.
Ref 530993GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease. IDrugs. 2010 Jul;13(7):472-81.
Ref 532026Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29.

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