Drug General Information
Drug ID
D01LDQ
Former ID
DNC011289
Drug Name
Mycophenolic hydroxamic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531203]
Structure
Download
2D MOL

3D MOL

Formula
C17H21NO6
Canonical SMILES
CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)NO)OC
InChI
1S/C17H21NO6/c1-9(5-7-13(19)18-22)4-6-11-15(20)14-12(8-24-17(14)21)10(2)16(11)23-3/h4,20,22H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChIKey
XUEGRBSFQYYISJ-RUDMXATFSA-N
PubChem Compound ID
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase 1 Target Info Inhibitor [531203]
Inosine-5'-monophosphate dehydrogenase 2 Target Info Inhibitor [531203]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Guanosine ribonucleotides de novo biosynthesisPWY-6353:Purine nucleotides degradation
Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathwayshsa00230:Purine metabolism
Metabolic pathways
PANTHER Pathway De novo purine biosynthesis
PathWhiz Pathway Purine Metabolism
Reactome Purine ribonucleoside monophosphate biosynthesisR-HSA-73817:Purine ribonucleoside monophosphate biosynthesis
WikiPathways Nucleotide Metabolism
References
Ref 531203Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. Epub 2010 Sep 18.Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells amongthe mycophenolic acid derivatives.
Ref 531203Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. Epub 2010 Sep 18.Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells amongthe mycophenolic acid derivatives.

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