Drug Information

Drug General Information
Drug ID
D02BJB
Former ID
DIB020828
Drug Name
RO116-9132/238
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542822]
Structure
Download
2D MOL
Formula
C28H40Cl2N3O4+
InChI
InChI=1S/C28H39Cl2N3O4/c1-18(2)24(32-28(34)31-21-15-25(35-4)27(37-6)26(16-21)36-5)17-33(3)11-9-19(10-12-33)13-20-7-8-22(29)23(30)14-20/h7-8,14-16,18-19,24H,9-13,17H2,1-6H3,(H-,31,32,34)/p+1/t19?,24-,33?/m0/s1
InChIKey
INQAQQXKVUWERW-WXJUUJJFSA-O
PubChem Compound ID
9915610
PubChem Substance ID
14886091, 45987263, 80910152, 135650913, 230836684, 249219564
Target and Pathway
Target(s) mRNA of CCR3 chemokine Target Info Antagonist [526363]
NetPath Pathway IL3 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
References
Ref 542822(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 790).
Ref 526363Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9.

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