Drug Information

Drug General Information
Drug ID
D02ONT
Former ID
DIB006959
Drug Name
5-FP
Synonyms
5-Fluoro-2(1H)-pyrimidinone
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [530233]
Structure
Download
2D MOL

3D MOL
Formula
C4H3FN2O
Canonical SMILES
C1=C(C=NC(=O)N1)F
InChI
1S/C4H3FN2O/c5-3-1-6-4(8)7-2-3/h1-2H,(H,6,7,8)
InChIKey
HPABFFGQPLJKBP-UHFFFAOYSA-N
PubChem Compound ID
101498
PubChem Substance ID
482895, 6246252, 10232087, 10512737, 15264757, 24884205, 26719753, 44431519, 46386867, 49681779, 52731551, 57337398, 60195718, 83104092, 91701277, 91849547, 92308424, 103145095, 104364453, 117506129, 124659022, 125520233, 126639749, 128003296, 128092552, 132629832, 135057887, 140349084, 143068206, 160827434, 162022178, 162237190, 163093211, 163391864, 163843338, 164202019, 164784370, 172080408, 179295976, 198985851, 204385775, 223578610, 223843422, 226648477, 241038813, 241052539, 242074146, 249774070, 249782080, 249826755
Target and Pathway
Target(s) Human DNA Target Info Binder [526595]
References
Ref 530233Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J Med Chem. 1991 Nov;34(11):3280-4.
Ref 526595Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time. Clin Cancer Res. 2003 Apr;9(4):1235-9.

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