Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02XJJ
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| Drug Name |
LM11A-31
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| Synonyms |
LM11A-31
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| Target and Pathway | |||||
| Target(s) | Tumor necrosis factor receptor superfamily member 16 | Target Info | Modulator | ||
| Pathway Interaction Database | p75(NTR)-mediated signaling | ||||
| Neurotrophic factor-mediated Trk receptor signaling | |||||
| Reactome | Axonal growth inhibition (RHOA activation) | ||||
| NRAGE signals death through JNK | |||||
| p75NTR negatively regulates cell cycle via SC1 | |||||
| Regulated proteolysis of p75NTR | |||||
| NADE modulates death signalling | |||||
| NRIF signals cell death from the nucleus | |||||
| p75NTR recruits signalling complexes | |||||
| NF-kB is activated and signals survival | |||||
| Axonal growth stimulation | |||||
| References | |||||
| Ref 1559605 | A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.Stem Cells.2013 Nov;31(11):2561-74. | ||||
| Ref 1559606 | A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.PLoS One.2014 Aug 25;9(8):e102136. | ||||
| Ref 1559923 | Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.Neurobiol Aging.2013 Aug;34(8):2052-63. | ||||
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