Drug Information

Drug General Information
Drug ID
D03VOB
Former ID
DNC010207
Drug Name
9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530305]
Structure
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2D MOL

3D MOL
Formula
C10H16N5O5P
Canonical SMILES
CC(CP(=O)(O)O)OCCN1C=NC2=C1NC(=NC2=O)N
InChI
1S/C10H16N5O5P/c1-6(4-21(17,18)19)20-3-2-15-5-12-7-8(15)13-10(11)14-9(7)16/h5-6H,2-4H2,1H3,(H2,17,18,19)(H3,11,13,14,16)
InChIKey
XUOAETDFEFTPTL-UHFFFAOYSA-N
PubChem Compound ID
45101444
Target and Pathway
Target(s) Hypoxanthine-guanine phosphoribosyltransferase Target Info Inhibitor [530305]
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathways
PathWhiz Pathway Purine Metabolism
Reactome Purine salvage
WikiPathways Nucleotide Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
Metabolism of nucleotides
References
Ref 530305Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Ref 530305Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

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