Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03VOB
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| Former ID |
DNC010207
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| Drug Name |
9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C10H16N5O5P
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| Canonical SMILES |
CC(CP(=O)(O)O)OCCN1C=NC2=C1NC(=NC2=O)N
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| InChI |
1S/C10H16N5O5P/c1-6(4-21(17,18)19)20-3-2-15-5-12-7-8(15)13-10(11)14-9(7)16/h5-6H,2-4H2,1H3,(H2,17,18,19)(H3,11,13,14,16)
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| InChIKey |
XUOAETDFEFTPTL-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Hypoxanthine-guanine phosphoribosyltransferase | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Purine metabolism | ||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Reactome | Purine salvage | ||||
| WikiPathways | Nucleotide Metabolism | ||||
| Mesodermal Commitment Pathway | |||||
| Endoderm Differentiation | |||||
| Metabolism of nucleotides | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | ||||
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