Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T41666
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| Former ID |
TTDR00219
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| Target Name |
Hypoxanthine-guanine phosphoribosyltransferase
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| Gene Name |
LACZ
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| Synonyms |
GPRT; Guanine phosphoribosyltransferase; HGPRT; HGPRTase; HPRT; Hypoxanthine phosphoribosyltransferase; LACZ
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| Target Type |
Research
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| Function |
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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| BioChemical Class |
Pentosyltransferase
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| Target Validation |
T41666
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| UniProt ID | |||||
| EC Number |
EC 2.4.2.8
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| Sequence |
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL |
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| Structure |
1CJB; 2VFA; 3OZF; 3OZG; 1BZY; 1D6N; 1HMP; 1Z7G; 2VFA; 3GEP; 3GGC; 3GGJ; 4IJQ; 4KN6; 4RAB; 4RAC; 4RAD; 4RAN; 4RAO; 4RAQ
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| Inhibitor | 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol | Drug Info | [1] | ||
| 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine | Drug Info | [1] | |||
| 7-Hydroxy-Pyrazolo[4,3-D]Pyrimidine | Drug Info | [2] | |||
| 9-Deazaguanine | Drug Info | [1] | |||
| 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine | Drug Info | [3] | |||
| 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine | Drug Info | [3] | |||
| 9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine | Drug Info | [3] | |||
| Acetate Ion | Drug Info | [1] | |||
| Alpha-Phosphoribosylpyrophosphoric Acid | Drug Info | [4] | |||
| Carboxylic PRPP | Drug Info | [1] | |||
| Formic Acid | Drug Info | [1] | |||
| Formycin B | Drug Info | [1] | |||
| Guanosine-5',3'-Tetraphosphate | Drug Info | [1] | |||
| Guanosine-5'-Monophosphate | Drug Info | [1] | |||
| Inosinic Acid | Drug Info | [1] | |||
| Pyrophosphate 2- | Drug Info | [4] | |||
| Pathways | |||||
| KEGG Pathway | Purine metabolism | ||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Reactome | Purine salvage | ||||
| WikiPathways | Nucleotide Metabolism | ||||
| Mesodermal Commitment Pathway | |||||
| Endoderm Differentiation | |||||
| Metabolism of nucleotides | |||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
| REF 3 | Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | ||||
| REF 4 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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