Drug General Information
Drug ID
Former ID
Drug Name
Acetate Ion
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]


Canonical SMILES
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) D-amino acid aminotransferase Target Info Inhibitor [551393]
MMP-12 Target Info Inhibitor [551393]
Superoxide dismutase [Cu-Zn] Target Info Inhibitor [551393]
4-aminobutyrate aminotransferase, mitochondrial Target Info Inhibitor [551393]
Angiotensin-converting enzyme Target Info Inhibitor [551393]
Glucosamine-6-phosphate synthase Target Info Inhibitor [551393]
Mannose-6-phosphate isomerase Target Info Inhibitor [551393]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Target Info Inhibitor [551393]
mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [551393]
Elastase 1 Target Info Inhibitor [551393]
Alanine racemase,biosynthetic Target Info Inhibitor [551393]
Hypoxanthine-guanine phosphoribosyltransferase Target Info Inhibitor [551393]
Nitric-oxide synthase, endothelial Target Info Inhibitor [551393]
Carbonic anhydrase II Target Info Inhibitor [551393]
Estrogen receptor beta Target Info Inhibitor [551393]
4-hydroxyphenylpyruvate dioxygenase Target Info Inhibitor [551393]
Thioredoxin Target Info Inhibitor [551393]
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase Target Info Inhibitor [551393]
Leukotriene A-4 hydrolase Target Info Inhibitor [551393]
Calmodulin Target Info Inhibitor [551393]
Thymidine monophosphate kinase Target Info Inhibitor [551393]
Aldo-keto reductase family 1 member C3 Target Info Inhibitor [551393]
Phospholipase A2 Target Info Inhibitor [551393]
Beta-lactamase Target Info Inhibitor [551393]
BioCyc Pathway Reactive oxygen species degradationGLUDEG-I-PWY:GABA shunt
Valine degradation
Beta-alanine degradation
4-aminobutyrate degradationPWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY66-375:Leukotriene biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesisLIPASYN-PWY:Phospholipases
KEGG Pathway Peroxisome
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Prion diseaseshsa00250:Alanine, aspartate and glutamate metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
Metabolic pathways
GABAergic synapsehsa04614:Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)hsa04520:Adherens junction
Insulin signaling pathwayhsa00330:Arginine and proline metabolism
Calcium signaling pathway
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa00240:Pyrimidine metabolism
Metabolic pathwayshsa00230:Purine metabolism
Drug metabolism - other enzymes
Metabolic pathwayshsa00330:Arginine and proline metabolism
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathwayhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa04915:Estrogen signaling pathway
Prolactin signaling pathwaymmu00130:Ubiquinone and other terpenoid-quinone biosynthesis
Tyrosine metabolism
Phenylalanine metabolism
Metabolic pathwayshsa00590:Arachidonic acid metabolism
Metabolic pathwayshsa04014:Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Amphetamine addiction
Gliomamtu00240:Pyrimidine metabolism
Metabolic pathwayshsa00140:Steroid hormone biosynthesis
Arachidonic acid metabolism
Ovarian steroidogenesishsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Ras signaling pathway
Fat digestion and absorption
NetPath Pathway IL1 Signaling Pathway
IL5 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_8:Wnt Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling PathwayNetPath_14:IL2 Signaling Pathway
RANKL Signaling PathwayNetPath_21:RANKL Signaling Pathway
TSH Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Aminobutyrate degradation
Pyrimidine Metabolism
Gamma-aminobutyric acid synthesisP02739:De novo pyrimidine deoxyribonucleotide biosynthesisP00012:Cadherin signaling pathwayP06959:CCKR signaling map STP00005:Angiogenesis
Endothelin signaling pathway
Interleukin signaling pathway
PI3 kinase pathway
VEGF signaling pathwayP00030:Hypoxia response via HIF activation
Oxidative stress responseP06959:CCKR signaling map ST
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingera_genomic_pathway:Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor networkinsulin_pathway:Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
SHP2 signaling
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha networkp38_mkk3_6pathway:p38 MAPK signaling pathway
TNF receptor signaling pathwaybcr_5pathway:BCR signaling pathway
p38 MAPK signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2 signaling events mediated by PI3K
IFN-gamma pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ErbB1 downstream signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Calcium signaling in the CD4+ TCR pathway
Insulin-mediated glucose transport
N-cadherin signaling events
Cellular roles of Anthrax toxin
Regulation of Ras family activation
Downstream signaling in na&#xef
Fc-epsilon receptor I signaling in mast cells
PathWhiz Pathway Degradation of SuperoxidesPW000002:Aspartate Metabolism
Glutamate Metabolism
Beta-Alanine Metabolism
Valine, Leucine and Isoleucine Degradation
Propanoate MetabolismPW000563:Angiotensin MetabolismPW000010:Arginine and Proline MetabolismPW000160:Pyrimidine MetabolismPW000052:Purine MetabolismPW000052:Purine MetabolismPW000044:Arachidonic Acid MetabolismPW000564:Muscle/Heart ContractionPW000044:Arachidonic Acid Metabolism
Reactome Collagen degradation
Degradation of the extracellular matrixR-HSA-114608:Platelet degranulation
Detoxification of Reactive Oxygen SpeciesR-HSA-2022377:Metabolism of Angiotensinogen to AngiotensinsR-HSA-354192:Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signalingR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-500753:Pyrimidine biosynthesisR-HSA-74217:Purine salvageR-HSA-1222556:ROS production in response to bacteria
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeabilityR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-2559580:Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
The NLRP3 inflammasomeR-HSA-111933:Calmodulin induced events
Platelet degranulation
Translocation of GLUT4 to the plasma membrane
DARPP-32 events
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
RHO GTPases activate IQGAPs
RAF/MAP kinase cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-975634:Retinoid metabolism and transportR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways TGF beta Signaling Pathway
Degradation of collagen
Matrix MetalloproteinasesWP408:Oxidative Stress
Copper homeostasis
Detoxification of Reactive Oxygen Species
Nifedipine Activity
Amyotrophic lateral sclerosis (ALS)
Dopamine metabolism
AGE/RAGE pathway
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP2685:GABA synthesis, release, reuptake and degradation
Alanine and aspartate metabolismWP554:ACE Inhibitor Pathway
Metabolism of Angiotensinogen to AngiotensinsWP481:Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signalingWP727:Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP1851:Metabolism of nucleotidesWP404:Nucleotide Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
Metabolism of nucleotidesWP554:ACE Inhibitor Pathway
EGF/EGFR Signaling Pathway
Corticotropin-releasing hormone
Endothelin Pathways
Metabolism of nitric oxide
AngiogenesisWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear ReceptorsWP2884:NRF2 pathway
Nuclear Receptors Meta-Pathway
Human Complement System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TNF alpha Signaling Pathway
Metabolism of nucleotides
Selenium Micronutrient NetworkWP2650:Arachidonic acid metabolism
Eicosanoid SynthesisWP2777:Translocation of GLUT4 to the Plasma Membrane
Visual phototransduction
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by the B Cell Receptor (BCR)
Inositol phosphate metabolism
DAG and IP3 signaling
Opioid Signalling
Muscle contraction
Metabolism of carbohydratesWP702:Metapathway biotransformation
Benzo(a)pyrene metabolism
Arachidonic acid metabolismWP2740:Glycerophospholipid biosynthesis
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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