Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T34287
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| Former ID |
TTDS00450
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| Target Name |
Mannose-6-phosphate isomerase
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| Gene Name |
PMI1
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| Synonyms |
PMI; Phosphohexomutase; Phosphomannose isomerase; PMI1
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| Target Type |
Successful
|
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| Disease | Acne vulgaris [ICD9: 706.1; ICD10: L70.0] | ||||
| Leprosy and dermatitis herpetiformis [ICD10: L13.0] | |||||
| Function |
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
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| BioChemical Class |
Intramolecular oxidoreductases
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| Target Validation |
T34287
|
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| UniProt ID | |||||
| EC Number |
EC 5.3.1.8
|
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| Sequence |
MSSEKLFRIQCGYQNYDWGKIGSSSAVAQFVHNSDPSITIDETKPYAELWMGTHPSVPSK
AIDLNNQTLRDLVTAKPQEYLGESIITKFGSSKELPFLFKVLSIEKVLSIQAHPDKKLGA QLHAADPKNYPDDNHKPEMAIAVTDFEGFCGFKPLDQLAKTLATVPELNEIIGQELVDEF ISGIKLPAEVGSQDDVNNRKLLQKVFGKLMNTDDDVIKQQTAKLLERTDREPQVFKDIDS RLPELIQRLNKQFPNDIGLFCGCLLLNHVGLNKGEAMFLQAKDPHAYISGDIIECMAASD NVVRAGFTPKFKDVKNLVEMLTYSYESVEKQKMPLQEFPRSKGDAVKSVLYDPPIAEFSV LQTIFDKSKGGKQVIEGLNGPSIVIATNGKGTIQITGDDSTKQKIDTGYVFFVAPGSSIE LTADSANQDQDFTTYRAFVEA |
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| Drugs and Mode of Action | |||||
| Drug(s) | Sulfacetamide | Drug Info | Approved | Acne vulgaris | [1], [2] |
| Sulfoxone | Drug Info | Approved | Leprosy and dermatitis herpetiformis | [2] | |
| Inhibitor | Acetate Ion | Drug Info | [3] | ||
| Formic Acid | Drug Info | [3] | |||
| GNF-PF-2272 | Drug Info | [4] | |||
| GNF-PF-5134 | Drug Info | [4] | |||
| NSC-66209 | Drug Info | [4] | |||
| Sulfacetamide | Drug Info | [5] | |||
| Sulfoxone | Drug Info | [5] | |||
| References | |||||
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 080028. | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 4 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
| REF 5 | Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54. | ||||
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