Drug General Information
Drug ID	D06EWG
Former ID	DNC003012
Drug Name	Formic Acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[467777]
Structure		Download 2D MOL 3D MOL
Formula	CHO2-
InChI	InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1
InChIKey	BDAGIHXWWSANSR-UHFFFAOYSA-M
CAS Number	CAS 64-18-6
PubChem Compound ID	283
PubChem Substance ID	2203, 2712, 841549, 4668969, 8143755, 8150550, 10533692, 14709153, 24438659, 50073763, 50817872, 57320099, 92729992, 92741270, 103036860, 104042951, 104294385, 126406823, 126687287, 127497873, 135269870, 137002191, 142323754, 160644736, 160644737, 160644738, 163218836, 178101261, 223444138, 223444139, 223749098
Target and Pathway
Target(s)	3-phosphoshikimate1-carboxyvinyltransferase	Target Info	Inhibitor	[551393]
	Mannose-6-phosphate isomerase	Target Info	Inhibitor	[551393]
	Nitric-oxide synthase, brain	Target Info	Inhibitor	[551393]
	Hypoxanthine-guanine phosphoribosyltransferase	Target Info	Inhibitor	[551393]
	Carbonic anhydrase II	Target Info	Inhibitor	[551393]
	Delta-aminolevulinic acid dehydratase	Target Info	Inhibitor	[551393]
	Peptide deformylase	Target Info	Inhibitor	[551393]
	Heme oxygenase	Target Info	Inhibitor	[551393]
	Glutathione S-transferase	Target Info	Inhibitor	[551393]
	Heparin-binding growth factor1	Target Info	Inhibitor	[551393]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-5920:Heme biosynthesis
	Tetrapyrrole biosynthesisPWY-5874:Heme degradationPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)hsa00230:Purine metabolism
	Drug metabolism - other enzymes
	Metabolic pathwayshsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00860:Porphyrin and chlorophyll metabolism
	Metabolic pathwayshsa00860:Porphyrin and chlorophyll metabolism
	HIF-1 signaling pathway
	Mineral absorption
	MicroRNAs in cancerhsa00590:Arachidonic acid metabolism
	Metabolic pathwayshsa04010:MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	PI3K-Akt signaling pathway
	Hippo signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Melanoma
NetPath Pathway	EGFR1 Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	CCKR signaling map STP02746:Heme biosynthesisP00005:Angiogenesis
	FGF signaling pathway
Pathway Interaction Database	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	HIF-1-alpha transcription factor networkfgf_pathway:FGF signaling pathway
PathWhiz Pathway	Arginine and Proline MetabolismPW000052:Purine MetabolismPW000158:Porphyrin MetabolismPW000158:Porphyrin Metabolism
Reactome	ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclaseR-HSA-74217:Purine salvageR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-917937:Iron uptake and transportR-HSA-109704:PI3K Cascade
	PIP3 activates AKT signaling
	FGFR4 ligand binding and activation
	FGFR3c ligand binding and activation
	FGFR2c ligand binding and activation
	FGFR2b ligand binding and activation
	FGFR3 mutant receptor activation
	Activated point mutants of FGFR2
	Constitutive Signaling by Aberrant PI3K in Cancer
	Phospholipase C-mediated cascade: FGFR1
	Phospholipase C-mediated cascade
	Phospholipase C-mediated cascade
	Phospholipase C-mediated cascade
	SHC-mediated cascade:FGFR1
	PI-3K cascade:FGFR1
	FRS-mediated FGFR1 signaling
	PI-3K cascade:FGFR2
	SHC-mediated cascade:FGFR2
	FRS-mediated FGFR2 signaling
	SHC-mediated cascade:FGFR3
	FRS-mediated FGFR3 signaling
	PI-3K cascade:FGFR3
	FRS-mediated FGFR4 signaling
	SHC-mediated cascade:FGFR4
	PI-3K cascade:FGFR4
	Negative regulation of FGFR1 signaling
	Negative regulation of FGFR2 signaling
	Negative regulation of FGFR3 signaling
	Negative regulation of FGFR4 signaling
	RAF/MAP kinase cascade
WikiPathways	Monoamine Transport
	Myometrial Relaxation and Contraction Pathways
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Alzheimers Disease
	Effects of Nitric Oxide
	Serotonin Transporter ActivityWP404:Nucleotide Metabolism
	Mesodermal Commitment Pathway
	Endoderm Differentiation
	Metabolism of nucleotidesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP561:Heme Biosynthesis
	Metabolism of porphyrinsWP408:Oxidative Stress
	Transcriptional activation by NRF2
	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2650:Arachidonic acid metabolism
	Aryl Hydrocarbon Receptor
	Integrated Pancreatic Cancer PathwayWP51:Regulation of Actin Cytoskeleton
	Differentiation Pathway
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	PIP3 activates AKT signaling
	Integrated Pancreatic Cancer Pathway
	Signaling by FGFR
References
Ref 467777	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4540).
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.