Target Information

Target General Infomation
Target ID
T18639
Former ID
TTDR00925
Target Name
Heparin-binding growth factor1
Gene Name
FGF1
Synonyms
AFGF; Acidic fibroblast growth factor; Beta-endothelial cell growth factor; ECGF-beta; Fibroblast growth factor 1; HBGF-1; FGF1
Target Type
Clinical Trial
Disease Coronary artery disease [ICD9: 410-414, 429.2; ICD10: I20-I25]
Critical limb ischemia [ICD9: 459.89; ICD10: I99.8]
Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
BioChemical Class
Growth factor
UniProt ID
P05230
Sequence
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQ
LSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEK
NWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
Drugs and Mode of Action
Drug(s) CVBT-141H Drug Info Phase 2 Coronary artery disease [547934]
Riferminogene pecaplasmid Drug Info Discontinued in Phase 3 Critical limb ischemia [546993]
Inhibitor 5-AMINO-NAPHTALENE-2-MONOSULFONATE Drug Info [551374]
Formic Acid Drug Info [551393]
N,O6-Disulfo-Glucosamine Drug Info [551393]
Naphthalene Trisulfonate Drug Info [551393]
O2-Sulfo-Glucuronic Acid Drug Info [551393]
Sucrose Octasulfate Drug Info [551393]
Modulator CVBT-141H Drug Info [549805]
Riferminogene pecaplasmid Drug Info [531175]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Hippo signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Melanoma
PANTHER Pathway Angiogenesis
FGF signaling pathway
Pathway Interaction Database FGF signaling pathway
Reactome PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
FGFR1
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
FGFR1
FGFR1
FRS-mediated FGFR1 signaling
FGFR2
FGFR2
FRS-mediated FGFR2 signaling
FGFR3
FRS-mediated FGFR3 signaling
FGFR3
FRS-mediated FGFR4 signaling
FGFR4
FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Differentiation Pathway
Organogenesis (Part 2 of 3)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Integrated Pancreatic Cancer Pathway
Signaling by FGFR
References
Ref 546993Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011879)
Ref 547934Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020529)
Ref 531175Riferminogene pecaplasmide. Am J Cardiovasc Drugs. 2010;10(5):343-6.
Ref 549805Clinical pipeline report, company report or official report of CVBT.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.