Drug Information

Drug General Information
Drug ID
D06ANS
Former ID
DIB014333
Drug Name
CVBT-141H
Synonyms
CVBT-141A; CVBT-141C; CVBT-141C); Cardio Vascu-Grow; FGF-1-141; Recombinant FGF-1 (coronary heart disease), CardioVascular Therapeutics; Recombinant FGF-1 (peripheral vascular disease), CardioVascular biotherapeutics
Indication Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] Phase 2 [547934]
Company
CardioVascular BioTherapeutics Inc; CardioVascular Biotherapeutics
Target and Pathway
Target(s) Heparin-binding growth factor1 Target Info Modulator [549805]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Hippo signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Melanoma
PANTHER Pathway Angiogenesis
FGF signaling pathway
Pathway Interaction Database FGF signaling pathway
Reactome PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Differentiation Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Integrated Pancreatic Cancer Pathway
Signaling by FGFR
References
Ref 547934Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020529)
Ref 549805Clinical pipeline report, company report or official report of CVBT.

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