Target Information

Target General Infomation
Target ID
T54065
Former ID
TTDR01019
Target Name
3-phosphoshikimate1-carboxyvinyltransferase
Gene Name
aroA
Synonyms
5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; aroA
Target Type
Research
Disease Malaria [ICD10: B54]
Function
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
BioChemical Class
Alkyl aryl transferase
UniProt ID
P0A6D3
EC Number
EC 2.5.1.19
Sequence
MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL
GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR
MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA
PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE
GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE
LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE
EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL
ARISQAA
Structure
1RF4; 1RF5; 1RF6; 1EPS; 1G6S; 1G6T; 1MI4; 1P88; 1P89; 1Q0I; 1Q0J; 1Q36; 1X8R; 1X8T; 2AA9; 2AAY; 2PQ9; 2QFQ; 2QFS; 2QFT; 2QFU; 3FJX; 3FJZ; 3FK0; 3FK1
Inhibitor Formic Acid Drug Info [551393]
Glyphosate Drug Info [536365]
Shikimate-3-Phosphate Drug Info [551393]
References
Ref 536365Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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