Drug General Information
Drug ID
D04AWP
Former ID
DNC003225
Drug Name
Guanosine-5'-Monophosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468188]
Structure
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2D MOL

3D MOL

Formula
C10H14N5O8P
InChI
InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey
RQFCJASXJCIDSX-UUOKFMHZSA-N
CAS Number
CAS 85-32-5
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [551393]
CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [551393]
DNA polymerase (HSV-2) Target Info Inhibitor [551393]
HCMV DNA polymerase Target Info Inhibitor [551393]
Hypoxanthine-guanine phosphoribosyltransferase Target Info Inhibitor [551393]
Presynaptic density protein 95 Target Info Inhibitor [551393]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathwayhsa00230:Purine metabolism
Drug metabolism - other enzymes
Metabolic pathwayshsa04390:Hippo signaling pathway
Glutamatergic synapse
Huntington's disease
Cocaine addiction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Huntington disease
Pathway Interaction Database ErbB4 signaling events
PathWhiz Pathway Purine Metabolism
Reactome cGMP effectsR-HSA-74217:Purine salvageR-HSA-399719:Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
WikiPathways Nucleotide Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
Metabolism of nucleotidesWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
L1CAM interactions
References
Ref 468188(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5123).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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