Drug Information

Drug General Information
Drug ID
D04NDM
Former ID
DAP000407
Drug Name
Paromomycin
Synonyms
Aminosidin; Catenulin; Humatin; Hydroxymycin sulfate; Neomycin E; Paramomycin Sulfate; Paromomycin I; Paromomycin sulfate Rx346208; Aminosidine, sulfate; HATT & Paromomycin; Humatin (TN); Paromomycin (INN); Paromomycin (TN); Paromomycin (complex); PA1-PA2-PA3-PA4; Human .alpha.-1-antitrypsin & Paromomyin; PAROMOMYCIN I, AMMINOSIDIN, CATENULIN, CRESTOMYCIN, MONOMYCIN A, NEOMYCIN E; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside; (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol; O-2-Amino-2-deoxy-.alpha.-D-glucopyranosyl-(1->4)-O-[O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1->3)-.beta.D-ribofuranosyl(1->5)]-2-deoxy-D-streptamine
Drug Type
Small molecular drug
Indication Acute and chronic intestinal amebiasis [ICD9: 6; ICD10:A06] Approved [538211]
Therapeutic Class
Antibiotics
Company
King Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C23H45N5O14
Canonical SMILES
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4<br />C(C(C(C(O4)CN)O)O)N)O)O)N
InChI
1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey
UOZODPSAJZTQNH-LSWIJEOBSA-N
CAS Number
CAS 1263-89-4
PubChem Compound ID
165580
PubChem Substance ID
4090, 600745, 629812, 7889687, 7889708, 7980252, 10255961, 24380735, 25628810, 26705725, 26707026, 26707296, 26718034, 26718038, 26718087, 26718092, 26737833, 26737866, 29195990, 29196150, 46239584, 46505391, 48416383, 49693301, 49693302, 49703371, 49829578, 49829580, 50139565, 56313066, 57350802, 76778425, 96024433, 104234223, 113456730, 123059634, 123059983, 126645008, 127294526, 127294527, 127294528, 127294529, 134213896, 134213903, 134337703, 135874467, 136349017, 136349597, 137004588, 143073336
SuperDrug ATC ID
A07AA06
SuperDrug CAS ID
cas=007542372
Target and Pathway
Target(s) 30S ribosomal subunit Target Info Binder [535431], [537314]
References
Ref 538211FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064171.
Ref 53543130S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli. Antimicrob Agents Chemother. 2002 May;46(5):1546-9.
Ref 537314Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30.

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