Target Information
Target General Infomation | |||||
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Target ID |
T72657
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Former ID |
TTDS00219
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Target Name |
30S ribosomal subunit
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Gene Name |
pbp2
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Synonyms |
30S ribosome subunit; pbp2
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Target Type |
Successful
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Disease | Acute and chronic intestinal amebiasis [ICD9: 6; ICD10: A06] | ||||
Acute hepatic failure; Alcoholic cirrhosis of liver [ICD9: 570, 571.1; ICD10: K71, K72] | |||||
Acne vulgaris [ICD9: 706.1; ICD10: L70.0] | |||||
Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99] | |||||
Lyme disease; Acne; Bronchitis [ICD10: L70, J20-J21, J42] | |||||
Skin infections [ICD9: 680-709; ICD10: L00-L99] | |||||
Target Validation |
T72657
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UniProt ID | |||||
Sequence |
MTENKGSSQPKKNGNNGGKSNSKKNRNVKRTIIKIIGFMIIAFFVVLLLGILLFAYYAWK
APAFTEAKLQDPIPAKIYDKNGELVKTLDNGQRHEHVNLKDVPKSMKDAVLATEDNRFYE HGALDYKRLFGAIGKNLTGGFGSEGASTLTQQVVKDAFLSQHKSIGRKAQEAYLSYRLEQ EYSKDDIFQVYLNKIYYSDGVTGIKAAAKYYFNKDLKDLNLAEEAYLAGLPQVPNNYNIY DHPKAAEDRKNTVLYLMHYHKRITDKQWEDAKKIDLKANLVNRTAEERQNIDTNQDSEYN SYVNFVKSELMNNKAFKDENLGNVLQSGIKIYTNMDKDVQKTLQNDVDNGSFYKNKDQQV GATILDSKTGGLVAISGGRDFKDVVNRNQATDPHPTGSSLKPFLAYGPAIENMKWATNHA IQDESSYQVDGSTFRNYDVKSHGTVSIYDALRQSFNIPALKAWQSVKQNAGNDAPKKFAA KLGLNYEGDIGPSEVLGGSASEFSPTQLASAFAAIANGGTYNNAHSIQKVVTRDGETIEY DHTSHKAMSDYTAYMLAEMLKGTFKPYGSAYGHGVSGVNMGAKTGTGTYGAETYSQYNLP DNAAKDVWINGFTPQYTMSVWMGFSKVKQYGENSFVGHSQQEYPQFLYENVMSKISSRDG EDFKRPSSVSGSIPSINVSGSQDNNTTNRSTHGGSDTSANSSGTAQSNNNTRSQQSRNSG GLTGIFN |
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Drugs and Mode of Action | |||||
Drug(s) | Amikacin | Drug Info | Approved | Bacterial infections | [536094] |
Clomocycline | Drug Info | Approved | Bacterial infections | [536600] | |
Demeclocycline | Drug Info | Approved | Lyme disease; Acne; Bronchitis | [551871] | |
Framycetin | Drug Info | Approved | Bacterial infections | [550693] | |
Kanamycin | Drug Info | Approved | Bacterial infections | [536472] | |
Lymecycline | Drug Info | Approved | Bacterial infections | [550671] | |
Meclocycline | Drug Info | Approved | Bacterial infections | [538215] | |
Methacycline | Drug Info | Approved | Bacterial infections | [550755] | |
Minocycline | Drug Info | Approved | Bacterial infections | [536447] | |
Neomycin | Drug Info | Approved | Acute hepatic failure; Alcoholic cirrhosis of liver | [538196], [542095] | |
Netilmicin | Drug Info | Approved | Bacterial infections | [536361] | |
Oxytetracycline | Drug Info | Approved | Bacterial infections | [538197] | |
Paromomycin | Drug Info | Approved | Acute and chronic intestinal amebiasis | [538211] | |
Rolitetracycline | Drug Info | Approved | Acne vulgaris | [536718], [551871] | |
Spectinomycin | Drug Info | Approved | Bacterial infections | [538593] | |
Streptomycin | Drug Info | Approved | Bacterial infections | [536838] | |
Tetracycline | Drug Info | Approved | Bacterial infections | [536773] | |
Tigecycline | Drug Info | Approved | Skin infections | [528128], [536254], [551186] | |
Binder | Amikacin | Drug Info | [534968] | ||
Clomocycline | Drug Info | [536600] | |||
Demeclocycline | Drug Info | [535969] | |||
Framycetin | Drug Info | [535064] | |||
Kanamycin | Drug Info | [535490] | |||
Lymecycline | Drug Info | [536284] | |||
Meclocycline | Drug Info | [535969] | |||
Methacycline | Drug Info | [536603] | |||
Minocycline | Drug Info | [536233] | |||
Neomycin | Drug Info | [536559] | |||
Netilmicin | Drug Info | [537813] | |||
Oxytetracycline | Drug Info | [535969] | |||
Paromomycin | Drug Info | [535431], [537314] | |||
Rolitetracycline | Drug Info | [536718] | |||
Spectinomycin | Drug Info | [535052] | |||
Streptomycin | Drug Info | [535052], [536345] | |||
Tetracycline | Drug Info | [535890] | |||
Tigecycline | Drug Info | [536254] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
DRM | DRM Info | ||||
References | |||||
Ref 528128 | Tigecycline (Tygacil): the first in the glycylcycline class of antibiotics. Proc (Bayl Univ Med Cent). 2006 Apr;19(2):155-61. | ||||
Ref 536094 | Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. | ||||
Ref 536254 | Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110. | ||||
Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
Ref 536447 | Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. | ||||
Ref 536472 | Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8. | ||||
Ref 536600 | Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5. | ||||
Ref 536718 | Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection for the separation of eight tetracyclines in honey samples. J Chromatogr A. 2008 Jun 27;1195(1-2):107-16. Epub 2008 May 10. | ||||
Ref 536773 | How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30. | ||||
Ref 536838 | Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22. | ||||
Ref 538196 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 060304. | ||||
Ref 538197 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 060634. | ||||
Ref 538211 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064171. | ||||
Ref 538215 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 065094. | ||||
Ref 538593 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050347. | ||||
Ref 534968 | Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9. | ||||
Ref 535052 | Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. | ||||
Ref 535431 | 30S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli. Antimicrob Agents Chemother. 2002 May;46(5):1546-9. | ||||
Ref 535490 | SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli. Genes Cells. 2002 Jul;7(7):629-38. | ||||
Ref 535969 | Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13. | ||||
Ref 536233 | Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. | ||||
Ref 536254 | Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110. | ||||
Ref 536284 | Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. | ||||
Ref 536345 | The interaction between streptomycin and ribosomal RNA. Biochimie. 1991 Dec;73(12):1431-8. | ||||
Ref 536559 | Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9. Epub 2007 Dec 5. | ||||
Ref 536600 | Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5. | ||||
Ref 536603 | Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6. | ||||
Ref 536718 | Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection for the separation of eight tetracyclines in honey samples. J Chromatogr A. 2008 Jun 27;1195(1-2):107-16. Epub 2008 May 10. |
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