Drug General Information
Drug ID
Former ID
Drug Name
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551391]


Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)[<br />O-])O.[Na+]
CAS Number
CAS 20398-34-9
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glycogen synthase kinase-3 beta Target Info Inhibitor [551391]
73-kDa molecular chaperone HSP73 Target Info Inhibitor [551391]
Phosphopantetheine adenylyltransferase Target Info Inhibitor [551391]
3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [551391]
Aurora kinase A Target Info Inhibitor [551391]
Pyridoxal kinase Target Info Inhibitor [551391]
Mast/stem cell growth factor receptor Target Info Inhibitor [551391]
Pantothenate kinase Target Info Inhibitor [551391]
Glutamate--cysteine ligase regulatorysubunit Target Info Inhibitor [551391]
Kinesin-like protein KIF11 Target Info Inhibitor [551391]
Thymidine monophosphate kinase Target Info Inhibitor [551391]
D-alanine--D-alanine ligase Target Info Inhibitor [551391]
Heat shock protein HSP 90 Target Info Inhibitor [551391]
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase Target Info Inhibitor [551391]
Thymidine kinase Target Info Inhibitor [551391]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathwayPLPSAL-PWY:Pyridoxal 5'-phosphate salvage
KEGG Pathway ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
PI3K-Akt signaling pathway
Wnt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Dopaminergic synapse
Insulin signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Hepatitis C
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Basal cell carcinomahsa03040:Spliceosome
MAPK signaling pathway
Protein processing in endoplasmic reticulum
Antigen processing and presentation
Estrogen signaling pathway
Epstein-Barr virus infectionhsa00770:Pantothenate and CoA biosynthesis
Metabolic pathwayshsa00900:Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretionhsa04114:Oocyte meiosishsa00750:Vitamin B6 metabolism
Metabolic pathwayshsa04014:Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Acute myeloid leukemia
Central carbon metabolism in cancerhsa00480:Glutathione metabolism
Metabolic pathwaysmtu00240:Pyrimidine metabolism
Metabolic pathwaysmtc00473:D-Alanine metabolism
Peptidoglycan biosynthesis
Metabolic pathways
Vancomycin resistancehsa04141:Protein processing in endoplasmic reticulum
NOD-like receptor signaling pathway
Progesterone-mediated oocyte maturation
NetPath Pathway TCR Signaling Pathway
TSH Signaling Pathway
IL4 Signaling PathwayNetPath_17:IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_15:IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PDGF signaling pathway
PI3 kinase pathway
Wnt signaling pathway
Ras Pathway
CCKR signaling map STP00006:Apoptosis signaling pathway
Parkinson diseaseP00014:Cholesterol biosynthesisP02770:Pyridoxal phosphate salvage pathway
Vitamin B6 metabolism
Pathway Interaction Database LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
CDC42 signaling events
LKB1 signaling events
Canonical Wnt signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
C-MYC pathway
Regulation of Androgen receptor activity
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by Stem cell factor receptor (c-Kit)
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
p53 pathway
Trk receptor signaling mediated by PI3K and PLC-gammasmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
C-MYB transcription factor networkaurora_b_pathway:Aurora B signaling
Signaling by Aurora kinases
PLK1 signaling events
Aurora A signalingcmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)hdac_classii_pathway:Signaling events mediated by HDAC Class II
Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
Integrins in angiogenesis
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
ErbB receptor signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PathWhiz Pathway Steroid BiosynthesisPW000053:Vitamin B6 MetabolismPW000003:Glutamate Metabolism
Glutathione Metabolism
Cysteine Metabolism
Reactome Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-3371453:Regulation of HSF1-mediated heat shock response
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
mRNA Splicing - Major PathwayR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-2132295:MHC class II antigen presentation
KinesinsR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Regulation of actin dynamics for phagocytic cup formation
eNOS activation
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
EPHA-mediated growth cone collapse
VEGFR2 mediated vascular permeability
Anchoring of the basal body to the plasma membrane
Constitutive Signaling by EGFRvIII
WikiPathways DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
IL-6 signaling pathway
Wnt Signaling Pathway Netpath
Copper homeostasis
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Cardiac Hypertrophic Response
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
BDNF signaling pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
Regulation of Microtubule Cytoskeleton
TWEAK Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP410:Diurnally Regulated Genes with Circadian Orthologs
MAPK Signaling Pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
GABA synthesis, release, reuptake and degradation
Parkin-Ubiquitin Proteasomal System pathway
Membrane Trafficking
L1CAM interactionsWP1857:Metabolism of water-soluble vitamins and cofactorsWP430:Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol BiosynthesisWP437:EGF/EGFR Signaling Pathway
Gastric Cancer Network 1
APC/C-mediated degradation of cell cycle proteinsWP1857:Metabolism of water-soluble vitamins and cofactorsWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP3:Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
Metabolism of amino acids and derivatives
Trans-sulfuration and one carbon metabolism
Trans-sulfuration pathway
Phase II conjugation
Glutathione metabolismWP2679:MHC class II antigen presentation
KinesinsWP2884:NRF2 pathway
Aryl Hydrocarbon Receptor Pathway
Binding and Uptake of Ligands by Scavenger Receptors
Signaling by ERBB2
Fcgamma receptor (FCGR) dependent phagocytosis
Influenza Life Cycle
EBV LMP1 signaling
Aryl Hydrocarbon Receptor
TNF alpha Signaling Pathway
Arylhydrocarbon receptor (AhR) signaling pathway
Signaling by EGFR
Mitotic G2-G2/M phases
Metabolism of nitric oxide
NOD pathway
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January

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