Drug Information

Drug General Information
Drug ID
D04UTH
Former ID
DIB005808
Drug Name
Long-acting erythropoietin conjugate
Synonyms
HM-10760; HM-10760A; LAPS-EPO; Long-acting erythropoietin conjugate (LAPS, anemia); Long-acting erythropoietin conjugate (LAPS, anemia), Hanmi
Indication Anemia [ICD9: 280-285; ICD10:D50-D64] Phase 1 [522889]
Company
Hanmi pharmaceutical
Target and Pathway
Target(s) Erythropoietin ligand Target Info Modulator
KEGG Pathway Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathway Interaction Database HIF-2-alpha transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
WikiPathways EPO Receptor Signaling
Hematopoietic Stem Cell Differentiation
Differentiation Pathway
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 522889ClinicalTrials.gov (NCT01030315) A Study of HM10760A (Long-acting Erythropoietin) in Healthy Adult Caucasian and Japanese Subjects. U.S. National Institutes of Health.

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