Drug General Information
Drug ID	D05HKB
Former ID	DNC001236
Drug Name	RS 86
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[544694]
Structure		Download 2D MOL 3D MOL
Formula	C11H19BrN2O2
Canonical SMILES	CCN1C(=O)CC2(C1=O)CCN(CC2)C.Br
InChI	1S/C11H18N2O2.BrH/c1-3-13-9(14)8-11(10(13)15)4-6-12(2)7-5-11;/h3-8H2,1-2H3;1H
InChIKey	RKVCNLSYEWDGNX-UHFFFAOYSA-N
CAS Number	CAS 51382-46-8
PubChem Compound ID	87933
PubChem Substance ID	10222735, 12012608, 44419166, 49961022, 57334412, 74773496, 103118368, 103671789, 104395225, 117386047, 126427228, 135046365, 163110353, 172648414, 198966769, 204407478
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M5	Target Info	Agonist	[537751]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544694	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000634)
Ref 537751	The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist. Eur J Pharmacol. 1986 Jun 5;125(1):45-62.

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