Drug Information

Drug General Information
Drug ID
D05TIB
Former ID
DAP000342
Drug Name
Trospium
Synonyms
Spasmex; Spasmoplex; Trosec; Trospium chloride; IP-631; Regurin (TN); Sanctura (TN); Spasmex (TN); Spasmoplex (TN); Trosec (TN); Trospium chloride (JAN/USAN/INN); Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-hydroxy-, chloride, benzilate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate chloride; 3-Hydroxyspiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium) chloride benzilate; 6,10-Ethano-5-azoniaspiro(4.5)decan-8-ol, chloride, benzilate; 8-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride
Drug Type
Small molecular drug
Indication Overactive bladder disorder; Spasm [ICD9: 188, 596.51, 728.85; ICD10:C67, N32.81, R25.2] Approved [527466], [528278], [538569], [542503], [551871]
Therapeutic Class
Parasympatholytics
Company
Allergan Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C25H30NO3+
InChI
InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1
InChIKey
OYYDSUSKLWTMMQ-UHFFFAOYSA-N
CAS Number
CAS 10405-02-4
PubChem Compound ID
5596
PubChem Substance ID
4894299, 29224634, 46506398, 76043738, 85209974, 104309689, 124974071, 126408180, 137148158, 140328791, 141858143, 142615674, 160963557, 179226174, 187051783, 224440060, 227012664, 238997407, 245810171, 247650073
SuperDrug ATC ID
G04BD09
SuperDrug CAS ID
cas=010405024
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [536284]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 5274662004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
Ref 528278Trospium chloride: the European experience. Expert Opin Pharmacother. 2006 Jul;7(10):1373-80.
Ref 538569FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021595.
Ref 542503(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7480).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536284Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.

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