Drug Information

Drug General Information
Drug ID
D05UWI
Former ID
DNC002844
Drug Name
Parecoxib
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [522000], [539918]
Structure
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2D MOL

3D MOL
Formula
C19H18N2O4S
InChI
InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)
InChIKey
TZRHLKRLEZJVIJ-UHFFFAOYSA-N
PubChem Compound ID
119828
PubChem Substance ID
10238678, 14828797, 17397807, 29300637, 49829565, 50067919, 76546468, 99444910, 104236927, 104409301, 129337106, 135076077, 137039042, 137244309, 142086609, 160969477, 162169241, 174528197, 177749133, 178100244, 179225992, 198980232, 210275621, 210281280, 211536041, 223794316, 226400424, 249867344, 252553762
SuperDrug ATC ID
M01AH04
Target and Pathway
Target(s) Lactotransferrin Target Info Inhibitor [551374]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Reactome ROS production in response to bacteria
Amyloid formation
WikiPathways Latent infection of Homo sapiens with Mycobacterium tuberculosis
References
Ref 522000ClinicalTrials.gov (NCT00455117) Effect of Parecoxib on Post-craniotomy Pain. U.S. National Institutes of Health.
Ref 539918(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2895).
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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