Target Information

Target General Infomation
Target ID
T67801
Former ID
TTDR01148
Target Name
Lactotransferrin
Gene Name
LTF
Synonyms
Lactoferrin; LTF
Target Type
Clinical Trial
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Diabetic foot ulcer [ICD9: 707; ICD10: L88-L89]
Function
Transferrins are iron binding transport proteins which can bind two atoms of ferric iron in association with the binding of an anion, usually bicarbonate.lactoferroxins a, b and c have opioid antagonist activity. Lactoferroxin a shows preference for mu-receptor.
BioChemical Class
Peptidase
UniProt ID
P02788
EC Number
EC 3.4.21.-
Sequence
MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDS
PIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKG
GSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGA
DKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDE
AERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKD
KSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAAR
RARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYT
AGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHT
AVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNS
NERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRK
PVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNL
LFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK
Drugs and Mode of Action
Drug(s) Parecoxib Drug Info Phase 4 Discovery agent [522000], [539918]
Talactoferrin Drug Info Phase 3 Diabetic foot ulcer [522365]
HLF 1-11 Drug Info Phase 1/2 Bacterial infections [522079]
Nimesulide Drug Info Withdrawn from market Discovery agent [523284], [542424]
Inhibitor 3h-Indole-5,6-Diol Drug Info [551393]
Alpha-D-Fucose Drug Info [551393]
Alpha-D-Mannose Drug Info [551393]
Fucose Drug Info [551393]
Lauric Acid Drug Info [551393]
Nimesulide Drug Info [551378]
Nitrilotriacetic Acid Drug Info [551393]
Parecoxib Drug Info [551374]
Modulator HLF 1-11 Drug Info [527302]
Talactoferrin Drug Info [528590]
Pathways
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Reactome ROS production in response to bacteria
Amyloid formation
WikiPathways Latent infection of Homo sapiens with Mycobacterium tuberculosis
References
Ref 522000ClinicalTrials.gov (NCT00455117) Effect of Parecoxib on Post-craniotomy Pain. U.S. National Institutes of Health.
Ref 522079ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis. U.S. National Institutes of Health.
Ref 522365ClinicalTrials.gov (NCT00706862) Safety and Efficacy of Talactoferrin in Addition to Standard Chemotherapy in Patients With Non-small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 523284ClinicalTrials.gov (NCT01257126) Efficacy of Diclofenac Potassium vs Nimesulide in the Treatment of Fever and Pain in Children With Upper Respiratory Tract Infection. U.S. National Institutes of Health.
Ref 539918(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2895).
Ref 542424(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7401).
Ref 527302The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21.
Ref 528590Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: a phase 1/2 clinical study. Am J Surg. 2007 Jan;193(1):49-54.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551378Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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