Drug Information

Drug General Information
Drug ID
D0N0UC
Former ID
DNC002438
Drug Name
Lauric Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540924]
Structure
Download
2D MOL

3D MOL
Formula
C12H24O2
InChI
InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey
POULHZVOKOAJMA-UHFFFAOYSA-N
PubChem Compound ID
3893
PubChem Substance ID
5649, 71199, 587917, 819797, 819951, 821886, 822246, 826382, 830803, 830815, 832379, 833825, 838007, 838335, 3133731, 3718095, 5673162, 7849666, 7886898, 7888608, 7888612, 8014369, 8026553, 8026610, 8026623, 8026781, 8027199, 8027947, 8027951, 8027953, 8137853, 8145220, 8152452, 10507982, 11456907, 15195524, 17388953, 17389665, 24770717, 24874804, 24896365, 24896407, 24901204, 24901205, 26703021, 26703023, 26703378, 26703414, 26710306, 26710331
Target and Pathway
Target(s) Toll-like receptor 4 Target Info Inhibitor [551393]
Genome polyprotein Target Info Inhibitor [551393]
Lymphocyte antigen 96 Target Info Inhibitor [551393]
Lactotransferrin Target Info Inhibitor [551393]
3-oxoacyl-[acyl-carrier-protein] synthase II Target Info Inhibitor [551393]
Phospholipase A2, membrane associated Target Info Inhibitor [551393]
3-oxoacyl-[acyl-carrier-protein] synthase 1 Target Info Inhibitor [551393]
Hepatocyte nuclear factor 4-alpha Target Info Inhibitor [551393]
BioCyc Pathway Phospholipases
KEGG Pathway NF-kappa B signaling pathway
HIF-1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Influenza A
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritishsa04064:NF-kappa B signaling pathway
Toxoplasmosishsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorptionhsa04152:AMPK signaling pathway
Maturity onset diabetes of the young
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
IL6 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signalingtoll_endogenous_pathway:Endogenous TLR signalingglypican_1pathway:Glypican 1 networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
Reactome Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR3/TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complexR-HSA-140534:Ligand-dependent caspase activation
TRAF6 mediated induction of TAK1 complexR-HSA-1222556:ROS production in response to bacteria
Amyloid formationR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PIR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent cascade
Primary Focal Segmental Glomerulosclerosis FSGS
Spinal Cord Injury
Corticotropin-releasing hormone
Pathogenic Escherichia coli infection
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosisWP2795:Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophyWP2857:Mesodermal Commitment Pathway
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
AMPK Signaling
References
Ref 540924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5534).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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