Drug Information

Drug General Information
Drug ID
D0D8EY
Former ID
DIB009149
Drug Name
HLF 1-11
Synonyms
Antimicrobial peptides, AM-Pharma; HLF(1-11); Antimicrobial peptides (bacterial infections), AM-Pharma; Antimicrobial peptides (fungal infections), AM-Pharma; HLF 1-11, AM-Pharma; Human lactoferrin 1-11, AM-Pharma; Human lactoferrin peptides (antibacterial), AM-Pharma
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Phase 1/2 [522079]
Company
Pharming Group NV
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C(=O)([C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(<br />=O)[C@H](CCCNC(=N)N)NC(=O)CN)CCCNC(=N)N)CCCNC(=N)N)CCCN<br />C(=N)N)CO)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c2c([nH]c1<br />)cccc2)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C)CS)CCC(=O)N)C(C<br />)C
Target and Pathway
Target(s) Lactotransferrin Target Info Modulator [527302]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Reactome ROS production in response to bacteria
Amyloid formation
WikiPathways Latent infection of Homo sapiens with Mycobacterium tuberculosis
References
Ref 522079ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis. U.S. National Institutes of Health.
Ref 527302The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21.

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