Drug Information

Drug General Information
Drug ID
D06HKH
Former ID
DNC002486
Drug Name
Beta-Mercaptoethanol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C2H6OS
Canonical SMILES
C(CS)O
InChI
1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
InChIKey
DGVVWUTYPXICAM-UHFFFAOYSA-N
CAS Number
CAS 60-24-2
PubChem Compound ID
1567
PubChem Substance ID
4181, 70162, 589479, 599920, 825659, 831555, 831821, 831822, 835442, 835443, 835444, 835445, 835446, 835447, 835448, 835449, 835450, 835451, 835456, 837880, 3133763, 5622934, 6436212, 6436356, 7886253, 7890431, 7979607, 8006454, 8006457, 8006460, 8006462, 8006465, 8006468, 8006471, 8006474, 8006477, 8006479, 8006482, 8006485, 8006488, 8006491, 8006494, 8006497, 8006500, 8006503, 8006506, 8006509, 8006512, 8006514, 8006517
Target and Pathway
Target(s) 3-beta-HSD Target Info Inhibitor [551393]
Thymidylate synthase Target Info Inhibitor [551393]
Heparin-binding growth factor 2 Target Info Inhibitor [551393]
M-phase inducer phosphatase 2 Target Info Inhibitor [551393]
High mobility group protein 1 Target Info Inhibitor [551393]
Adenylosuccinate synthetase Target Info Inhibitor [551393]
Carbonic anhydrase II Target Info Inhibitor [551393]
Delta-aminolevulinic acid dehydratase Target Info Inhibitor [551393]
Carbonic anhydrase Target Info Inhibitor [551393]
Dihydrofolate reductase Target Info Inhibitor [551393]
BioCyc Pathway Pyrimidine deoxyribonucleotides biosynthesis from CTP
Pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleoside salvage
DTMP de novo biosynthesis (mitochondrial)
Pyrimidine deoxyribonucleosides salvagePWY-5920:Heme biosynthesis
Tetrapyrrole biosynthesis
KEGG Pathway Pyrimidine metabolism
One carbon pool by folate
Metabolic pathwayshsa04010:MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Melanomahsa04010:MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancerhsa03410:Base excision repairhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00860:Porphyrin and chlorophyll metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling PathwayNetPath_14:IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling PathwayNetPath_23:TSH Signaling Pathway
TCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway De novo pyrimidine deoxyribonucleotide biosynthesis
Formyltetrahydroformate biosynthesisP00059:p53 pathwayP02746:Heme biosynthesis
Pathway Interaction Database E2F transcription factor networkglypican_1pathway:Glypican 1 network
Angiopoietin receptor Tie2-mediated signaling
Integrins in angiogenesis
Syndecan-4-mediated signaling events
FGF signaling pathwayplk1_pathway:PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signalingintegrin3_pathway:Beta3 integrin cell surface interactions
amb2 Integrin signaling
Endogenous TLR signaling
PathWhiz Pathway Pyrimidine MetabolismPW000158:Porphyrin MetabolismPW000024:Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Pyrimidine biosynthesis
G1/S-Specific TranscriptionR-HSA-109704:PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascadeR-HSA-157881:Cyclin B2 mediated events
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entryR-HSA-1810476:RIP-mediated NFkB activation via ZBP1
Activation of DNA fragmentation factor
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activationR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-113510:E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
WikiPathways Trans-sulfuration and one carbon metabolism
Retinoblastoma (RB) in Cancer
One Carbon Metabolism
Integrated Pancreatic Cancer Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Metabolism of nucleotides
Fluoropyrimidine ActivityWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
Differentiation Pathway
Cardiac Hypertrophic Response
Syndecan interactions
Extracellular matrix organization
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Neural Crest Differentiation
miR-targeted genes in squamous cell - TarBase
Signaling by FGFR
MicroRNAs in cardiomyocyte hypertrophy
AngiogenesisWP615:Senescence and Autophagy in Cancer
MAPK Signaling Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G2-G2/M phases
Cell CycleWP710:DNA Damage Response (only ATM dependent)
Cytosolic sensors of pathogen-associated DNA
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Apoptotic execution phase
Advanced glycosylation endproduct receptor signalingWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP561:Heme Biosynthesis
Metabolism of porphyrins
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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