TTD | Drug: D06VWL

Drug General Information
Drug ID	D06VWL
Former ID	DNC009631
Drug Name	VA-106483
Drug Type	Small molecular drug
Indication	Nocturia [ICD10:R35]		Phase 2	[522905]
Structure		Download 2D MOL 3D MOL
Formula	C27H34N4O3
Canonical SMILES	CC1=C(C=CC(=C1)C(=O)N2CCCCC3=CC=CC=C32)CNC(=O)N4CCCC4C(<br />=O)N(C)C
InChI	1S/C27H34N4O3/c1-19-17-21(25(32)30-15-7-6-10-20-9-4-5-11-23(20)30)13-14-22(19)18-28-27(34)31-16-8-12-24(31)26(33)29(2)3/h4-5,9,11,13-14,17,24H,6-8,10,12,15-16,18H2,1-3H3,(H,28,34)/t24-/m0/s1
InChIKey	RUOLFWZIFNQQGH-DEOSSOPVSA-N
PubChem Compound ID	10298385
Target and Pathway
Target(s)	Vasopressin V2 receptor	Target Info	Inhibitor	[529841]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Vasopressin-regulated water reabsorption
Pathway Interaction Database	Arf6 trafficking events
PathWhiz Pathway	Vasopressin Regulation of Water Homeostasis
Reactome	Vasopressin-like receptors
	G alpha (s) signalling events
	Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways	GPCRs, Class A Rhodopsin-like
	Regulation of Water Balance by Renal Aquaporins
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522905	ClinicalTrials.gov (NCT01038843) Efficacy Study of VA106483 in Males With Nocturia.. U.S. National Institutes of Health.
Ref 529841	J Med Chem. 2008 Dec 25;51(24):8124-34.New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists.

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Drug Information