Drug General Information
Drug ID
D06WYG
Former ID
DIB000119
Drug Name
99mTc-MIP-1407
Synonyms
MIP-1407; MIP-1407-[99mTc]; Somatostatin receptor modulator imaging agent (neuroendocrine cancer), Molecular Insight; Technetium-99m-MIP-1407
Indication Neuroendocrine cancer [ICD10:C7A] Investigative [543791]
Company
Molecular Insight Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL

Canonical SMILES
c1cnc(n1CN(CCCC[C@H](N)C(=O)N[C@@H](C(=O)N[C@@H]1C(=O)N<br />[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](<br />C(=O)N[C@@H]([C@H](O)C)CO)CSSC1)[C@H](O)C)CCCCN)Cc1c[nH<br />]c2c1cccc2)Cc1ccc(cc1)O)Cc1ccccc1)Cn1ccnc1CC(=O)O)CC(=O<br />)O.[99Tc].[C-]#[O+].[C-]#[O+].[C-]#[O+]
Target and Pathway
Target(s) Somatostatin receptor 1 Target Info Modulator [530618], [532210]
Somatostatin receptor type 3 Target Info Modulator [530618], [532210]
Somatostatin receptor type 2 Target Info Modulator [543788]
Somatostatin receptor type 4 Target Info Modulator [543790]
Somatostatin receptor type 5 Target Info Modulator [543791]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04080:Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 543791(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 359).
Ref 530618Mol Endocrinol. 2010 Feb;24(2):436-46. Epub 2010 Jan 5.Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 543788(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 356).
Ref 543790(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 358).
Ref 543791(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 359).

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