Drug Information

Drug General Information
Drug ID
D06XWB
Former ID
DNC000749
Drug Name
Huperzine A
Drug Type
Small molecular drug
Indication Epileptic seizures; Alzheimer disease [ICD9: 345.9, 780.3, 331; ICD10:G40, P90, R56, G30] Approved [544707], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C15H18N2O
Canonical SMILES
CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3
InChI
1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
InChIKey
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
CAS Number
CAS 102518-79-6
PubChem Compound ID
5912039
PubChem Substance ID
24895708, 26756604, 29215281, 46511199, 46511231, 49991754, 49991755, 81041173, 85787773, 87462092, 91704460, 99301010, 99302530, 124892414, 134339656, 134339657, 134339658, 134340090, 135256104, 138769941, 142457861, 162093277, 162226717, 163395960, 163621066, 163686389, 163843547, 164758826, 180372184, 184548364, 216261296, 223435570, 226974040, 227296699, 242084598, 252455822
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [535553]
NMDA receptor Target Info Antagonist [536934]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 544707Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000687)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535553Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70.
Ref 536934Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. Epub 2008 Nov 12.

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