Target Information

Target General Infomation
Target ID
T30082
Former ID
TTDS00140
Target Name
Acetylcholinesterase
Gene Name
ACHE
Synonyms
AChE; ACHE
Target Type
Successful
Disease Alzheimer disease; Mild cognitive impairment [ICD9: 331.0, 331.83; ICD10: F06.7, G30, G31.84]
Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Alzheimer disease [ICD9: 331; ICD10: G30]
Chronic glaucoma [ICD9: 365; ICD10: H40-H42]
Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Epileptic seizures; Alzheimer disease [ICD9:345.9, 780.3, 331; ICD10: G40, P90, R56, G30]
Glaucoma [ICD9: 365; ICD10: H40-H42]
Helminth infection [ICD9: 001-139; ICD10: A00-B99]
Myasthenia gravis [ICD9: 358; ICD10: G70.0]
Myasthenia gravis diagnosis [ICD9: 358; ICD10: G70.0]
Neurodegenerative disease [ICD9: 330-337; ICD10: G30-G32]
Open-angle glaucoma; Anxiety disorder [ICD9:365, 300, 311; ICD10: H40-H42, F32, F40-F42]
Poisoning due to pesticides and chemicals [ICD10: T36-T50]
Poison intoxication [ICD10: T36-T50]
Parkinson's disease [ICD9: 332; ICD10: G20]
Pediculus humanus capitis [ICD9: 132; ICD10: B85.0]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Upper abdominal bloating; Early satiation associated with functional dyspepsia [ICD9: 536.8; ICD10: K30]
Urinary dysfunction [ICD10: N39.3-N39.4]
Xerostomia [ICD9: 527.7; ICD10: K11.7, R68.2]
Unspecified [ICD code not available]
Function
Rapidly hydrolyzes choline released into the synapse.
BioChemical Class
Carboxylic ester hydrolase
Target Validation
T30082
UniProt ID
P22303
EC Number
EC 3.1.1.7
Sequence
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
Drugs and Mode of Action
Drug(s) Ambenonium Drug Info Approved Myasthenia gravis [538427]
Demecarium bromide Drug Info Approved Open-angle glaucoma; Anxiety disorder [538451], [551871]
Donepezil Drug Info Approved Alzheimer disease [541717], [544878], [551871]
Echothiophate Iodide Drug Info Approved Chronic glaucoma [538454]
Edrophonium Drug Info Approved Myasthenia gravis diagnosis [538168]
Galantamine Drug Info Approved Alzheimer disease [536285], [541798]
Huperzine A Drug Info Approved Epileptic seizures; Alzheimer disease [544707], [551871]
Isoflurophate Drug Info Approved Glaucoma [536300]
Malathion Drug Info Approved Pediculus humanus capitis [538333]
Neostigmine Drug Info Approved Myasthenia gravis [550269]
Pralidoxime Chloride Drug Info Approved Poisoning due to pesticides and chemicals [551871]
Pyridostigmine Drug Info Approved Myasthenia gravis [538182]
Rivastigmine Drug Info Approved Alzheimer disease [522744], [541722]
Tacrine Drug Info Approved Alzheimer disease [536361], [541792]
YM443 Drug Info Approved Upper abdominal bloating; Early satiation associated with functional dyspepsia [551871]
(-)-Phenserine Drug Info Phase 3 Alzheimer disease [532220]
Amocarzine Drug Info Phase 3 Helminth infection [534433]
Eptastigmine Drug Info Phase 3 Cognitive disorders [526265]
INM-176 Drug Info Phase 3 Alzheimer disease [523260]
Suronacrine maleate Drug Info Phase 3 Cognitive disorders [551848]
Ladostigil Drug Info Phase 2 Alzheimer disease [531772]
Methanesulfonyl fluoride Drug Info Phase 2 Alzheimer disease [549186]
R-phenserine Drug Info Phase 2 Alzheimer disease; Mild cognitive impairment [548049]
T-82 Drug Info Phase 2 Cognitive disorders [526578]
Desoxypeganine Drug Info Phase 1 Alcohol use disorders [529540]
KW-5092 Drug Info Phase 1 Pain [534378]
PRX-105 Drug Info Phase 1 Poison intoxication [522989]
ZT-1 Drug Info Phase 1 Parkinson's disease [532328]
PHENSERINE TARTRATE Drug Info Preclinical Parkinson's disease [547033]
SPH-1285 Drug Info Preclinical Alzheimer disease [547351]
VELNACRINE Drug Info Discontinued in Phase 3 Cognitive disorders [527051]
Zanapezil Drug Info Discontinued in Phase 3 Alzheimer disease [545741]
Caracemide Drug Info Discontinued in Phase 2 Cancer [544726]
HP-290 Drug Info Discontinued in Phase 2 Parkinson's disease [546136]
Icopezil maleate Drug Info Discontinued in Phase 2 Cognitive disorders [546140]
Physostigmine Drug Info Discontinued in Phase 2 Xerostomia [541716], [548786]
S-9977 Drug Info Discontinued in Phase 2 Cognitive disorders [544962]
SM-10888 Drug Info Discontinued in Phase 2 Cognitive disorders [544850]
TAK-802 Drug Info Discontinued in Phase 2 Urinary dysfunction [547886]
ZIFROSILONE Drug Info Discontinued in Phase 2 Cognitive disorders [545006]
NP-61 Drug Info Discontinued in Phase 1 Alzheimer disease [548783]
7-methoxytacrine Drug Info Terminated Discovery agent [545830]
ABS-301 Drug Info Terminated Alzheimer disease [546251]
CI-1002 Drug Info Terminated Alzheimer disease [533784]
F-3796 Drug Info Terminated Alzheimer disease [545742]
FR-152558 Drug Info Terminated Alzheimer disease [546174]
MF-8615 Drug Info Terminated Alzheimer disease [546215]
MF268 Drug Info Terminated Alzheimer disease [546262]
NP-7557 Drug Info Terminated Alzheimer disease [547586]
Ro-46-5934 Drug Info Terminated Alzheimer disease [533753]
Inhibitor (+/-)-huprineY hydrochloride Drug Info [528570]
(-)-huperzine B Drug Info [529473]
(-)-Phenserine Drug Info [551218]
(-)-Tolserine Drug Info [551218]
(1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE Drug Info [551374]
(2-Butyryloxy-ethyl)-trimethyl-ammonium iodide Drug Info [534296]
(2-Chloro-ethyl)-trimethyl-ammonium chloride Drug Info [534296]
(2-Ethoxy-ethyl)-trimethyl-ammonium iodide Drug Info [534296]
(2-Mercapto-ethyl)-trimethyl-ammonium iodide Drug Info [534296]
(24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol Drug Info [527846]
(3-Bromo-propyl)-trimethyl-ammonium Drug Info [534296]
(3-Hydroxy-2-methyl-phenyl)-trimethyl-ammonium Drug Info [534296]
(3R)-9-amino-3-methyl-1,2,3,4-tetrahydroacridine Drug Info [530551]
(4-Bromo-butyl)-trimethyl-ammonium Drug Info [534296]
(4-Iodo-butyl)-trimethyl-ammonium iodide Drug Info [534296]
(5-Bromo-pentyl)-trimethyl-ammonium Drug Info [534296]
(R)-tacrine(10)-hupyridone Drug Info [551374]
(RS)-tacrine(10)-hupyridone Drug Info [529473]
(S)-tacrine(10)-hupyridone Drug Info [551374]
(S,S)-(-)-bis(10)-hupyridone Drug Info [529473]
(S,S)-(-)-bis(12)-hupyridone Drug Info [529473]
1,10-bis(pyridinium)-decane dibromide Drug Info [530696]
1,11-bis(pyridinium)-undecane dibromide Drug Info [530696]
1,2-Di(berberine-9-O-yl)ethane dibromide Drug Info [530920]
1,2-NAPHTHOQUINONE Drug Info [529103]
1,3-Bis-(3-imidazolidin-2-yl-phenyl)-urea Drug Info [527214]
1,3-Di(berberine-9-O-yl)ethane dibromide Drug Info [530920]
1,4-Di(berberine-9-O-yl)ethane dibromide Drug Info [530920]
1,9-bis(pyridinium)-nonane dibromide Drug Info [530696]
1-(3-Bromomethyl-phenyl)-2,2,2-trifluoro-ethanone Drug Info [526149]
1-benzene sulfonyl-cis-2,6-dimethyl piperidine Drug Info [530187]
1-Deoxy-1-Thio-Heptaethylene Glycol Drug Info [551374]
1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE Drug Info [551374]
10-Hydroxy-infractopicrin Drug Info [530743]
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine Drug Info [528402]
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Drug Info [551393]
2-(N-Morpholino)-Ethanesulfonic Acid Drug Info [551393]
2-Hex-5-enyl-5-non-8-enyl-3,4-dihydro-2H-pyrrole Drug Info [551277]
2-Hex-5-enyl-5-non-8-enyl-pyrrolidine Drug Info [551277]
2-Hex-5-enyl-5-nonyl-pyrrolidine Drug Info [551277]
2-morpholino-N-phenethylpyrimidin-4-amine Drug Info [530923]
2-Propyl-beta-carboline-2-ium iodide Drug Info [530824]
24-ethyl-cholest-7-ene-3,5,6-triol Drug Info [527846]
24-ethylcholest-6-ene-3,5-diol Drug Info [527846]
3,4,5,6-Tetrachloro-[1,2]benzoquinone Drug Info [527510]
3,6,9,12,15-Pentaoxaheptadecane Drug Info [551374]
3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM Drug Info [551374]
3-(2,5-Dioxo-pyrrolidin-1-yl)-benzoic acid Drug Info [526619]
3-(2-Diethylamino-acetamino)-rutaecarpine Drug Info [530639]
3-(2-Diethylamino-propionamino)-rutaecarpine Drug Info [530639]
3-(2-N-Piperidyl-acetamino)-rutaecarpine Drug Info [530639]
3-(2-N-Piperidyl-propionamino)-rutaecarpine Drug Info [530639]
3-(2-N-Pyrrolyl-acetamino)-rutaecarpine Drug Info [530639]
3-(2-N-Pyrrolyl-propionamino)-rutaecarpine Drug Info [530639]
3-(3-Carboxy-propionylamino)-benzoic acid Drug Info [526619]
3-(4-Benzoylpiperazine-1-carbonyl)coumarin Drug Info [529641]
3-(4-o-Tolylpiperazine-1-carbonyl)coumarin Drug Info [529641]
3-(4-Phenylpiperazin-1-carbonyl)coumarin Drug Info [529641]
3-(dimethylamino)phenyl phenylcarbamate Drug Info [551218]
3-hydroxy-N,N,N-trimethylbenzenaminium iodide Drug Info [529567]
3-[(1s)-1-(Dimethylamino)Ethyl]Phenol Drug Info [551374]
3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1H-indazole Drug Info [527249]
3-[3-(benzylmethylamino)propoxy]xanthen-9-one Drug Info [528456]
3-[4-(benzylmethylamino)butoxy]xanthen-9-one Drug Info [528456]
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one Drug Info [528456]
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one Drug Info [528456]
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one Drug Info [528456]
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one Drug Info [528456]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [531079]
4-formylphenyl-O-beta-D-ribopyranoside Drug Info [528897]
4-formylphenyl-O-beta-Dglucopyranoside Drug Info [528897]
4-ISOPROPYLPHENSERINE Drug Info [530692]
4-[4-(benzhydryloxy)piperidino]butyl benzoate Drug Info [528979]
4ALPHA-(HYDROXYMETHYL)-4ALPHA-DEMETHYLTERRITREM B Drug Info [534457]
5,6-dinitroacenaphthoquinone Drug Info [529103]
5-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info [551237]
5-Hex-5-enyl-2-nonyl-3,4-dihydro-2H-pyrrole Drug Info [551277]
6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info [526093]
6-chlorotacrine hydrochloride Drug Info [530301]
6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-hydroxy-2,9-dimethyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-hydroxy-2-methyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole Drug Info [528415]
6-methoxy-2,9-dimethyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-methoxy-2-methyl-9H-beta-carbolin-2-ium Drug Info [528415]
6-Methyl-4-(4-benzoylpiperazin-1-yl)coumarin Drug Info [529641]
6-Methyl-4-(4-o-tolylpiperazin-1-yl)coumarin Drug Info [529641]
6-Methyl-4-(4-phenylpiperazin-1-yl)coumarin Drug Info [529641]
7-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info [551237]
7-methoxytacrine Drug Info [531150]
7-Oxo-7H-dibenzo[de,g]quinoline Drug Info [529985]
8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info [551237]
9-Amino-1,2,3,4-tetrahydro-acridine-1,7-diol Drug Info [551238]
9-amino-7H-dibenzo[de,h]quinolin-7-one Drug Info [529985]
9-Ethyl-2-methyl-beta-carboline-2-ium iodide Drug Info [530824]
9-Ethyl-beta-carboline Drug Info [530824]
9-hydrazino-1,2,3,4-tetrahydroacridine Drug Info [528564]
9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide Drug Info [530625]
9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide Drug Info [530625]
9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide Drug Info [530920]
9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide Drug Info [530920]
9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide Drug Info [530920]
9-O-[3-(Phenylamino)propyl]-berberine bromide Drug Info [530920]
9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide Drug Info [530625]
9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide Drug Info [530625]
9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide Drug Info [530625]
Alkylene Linked Bis-Galanthamine derivative Drug Info [525746]
Allyl-trimethyl-ammonium Drug Info [534296]
Ambenonium Drug Info [536540]
Amocarzine Drug Info [526781]
AP-2238 Drug Info [530741]
AP-2243 Drug Info [529149]
BENZOQUINONE Drug Info [527510]
Beta-L-fucose Drug Info [551391]
BIS(12)-HUPERZINE B Drug Info [527419]
Bis(14)-Huperzine B Drug Info [527419]
BIS(16)-HUPERZINE B Drug Info [527419]
BIS(18)-HUPERZINE B Drug Info [527419]
BIS(20)-HUPERZINE B Drug Info [527419]
BIS(8)-HUPERZINE B Drug Info [527419]
BIS(9)-HUPERZINE B Drug Info [527419]
Bis-7-tacrine Drug Info [530923]
But-3-enyl-trimethyl-ammonium bromide Drug Info [534296]
BW-28C51 Drug Info [529716]
BW284C51 Drug Info [526592]
BZYX Drug Info [543634]
CAPROCTAMINE Drug Info [529775]
Caracemide Drug Info [533460]
Carinatumins B (2) Drug Info [528591]
CHF-2819 Drug Info [528371]
CHLORANIL Drug Info [527510]
Chlorphrifos oxon Drug Info [529440]
CHLORPYRIFOS Drug Info [527865]
CHOLINE IODIDE Drug Info [534296]
Cis-2,6-dimethyl-1-methyl sulfonyl piperidine Drug Info [530187]
CLEBOPRIDE Drug Info [527214]
CORONARIDINE Drug Info [531166]
CRYPTADINE B Drug Info [529072]
DECIDIUM Drug Info [529473]
Demecarium bromide Drug Info [535708], [537819]
Dimethyl-pent-4-enyl-ammonium bromide Drug Info [534296]
Edrophonium Drug Info [537001], [537124], [537383]
Eptastigmine Drug Info [526265]
Ethyl octylfluorophosphonate Drug Info [529440]
ETHYLPHENSERINE Drug Info [531080]
F-3796 Drug Info [545743]
FR-152558 Drug Info [546175]
Fucose Drug Info [551393]
Galantamine Drug Info [537334], [537340], [537434]
Galanthamine derivative Drug Info [529473]
GANSTIGMINE Drug Info [529473]
GENESERINE Drug Info [528371]
HALOXYSTEROL A Drug Info [527846]
HALOXYSTEROL B Drug Info [527846]
Haloxysterol C Drug Info [527846]
Haloxysterol D Drug Info [527846]
HEPTYPHYSOSTIGMINE Drug Info [531080]
Hexyl-trimethyl-ammonium Drug Info [534296]
HP-290 Drug Info [525471]
Huperaine A Drug Info [551374]
Huperzine A Drug Info [535553]
Huprine X Drug Info [529473]
Huprine Y Drug Info [530171]
Huprine-Tacrine Heterodimer Drug Info [527471]
Icopezil maleate Drug Info [527249]
INFRACTOPICRIN Drug Info [530743]
INM-176 Drug Info [531983]
Iso-OMPA Drug Info [529716]
Isoflurophate Drug Info [535756]
Isopropyl dodecylfluorophosphonate Drug Info [529440]
Isosorbide-2-(methylcarbamate)-5-benzoate Drug Info [529716]
Isosorbide-2-(methylcarbamate)-5-mononitrate Drug Info [529716]
Isosorbide-2-benzylcarbamate-5-cyclopentanoate Drug Info [529716]
Isosorbide-2-benzylcarbamate-5-cyclopropanoate Drug Info [529716]
Isosorbide-2-benzylcarbamate-5-tosylate Drug Info [529716]
Isosorbide-di-(4-nitrophenyl carbamate) Drug Info [530646]
Isosorbide-di-(benzylcarbamate) Drug Info [530646]
Isosorbide-di-(ethylcarbamate) Drug Info [530646]
Isosorbide-di-phenylcarbamate Drug Info [530646]
KW-5092 Drug Info [534378]
Ladostigil Drug Info [531772]
LAWSARITOL Drug Info [527846]
LIPOCRINE Drug Info [530437]
LYSICAMINE Drug Info [551369]
Malathion Drug Info [537332]
MEMOQUIN Drug Info [530437]
MESUAGENIN A Drug Info [531213]
MESUAGENIN B Drug Info [531213]
Mesuagenin D Drug Info [531213]
Methanesulfonyl fluoride Drug Info [532098]
Methyl Phosphinic Acid Drug Info [551393]
Methylphosphonic Acid Ester Group Drug Info [551393]
MF-8615 Drug Info [546216]
MF268 Drug Info [551374]
Monoisopropylphosphorylserine Drug Info [551393]
N,N'-(1',10'-decylene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',6-hexylene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',8'-octylene)-bis-(-)-nor-MEP Drug Info [529368]
N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP Drug Info [529368]
N-(14-methylallyl)norgalanthamine Drug Info [529384]
N-ALLYLNORGALANTHAMINE Drug Info [529384]
N-allylnorlitebamine Drug Info [534555]
N-benzyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine Drug Info [530923]
N-benzyl-2-morpholinopyrimidin-4-amine Drug Info [530923]
N-benzyl-2-thiomorpholinopyrimidin-4-amine Drug Info [530923]
N-benzylnorlitebamine Drug Info [534555]
N-butylnorlitebamine Drug Info [534555]
N-isobutylnorlitebamine Drug Info [534555]
N-isopropylnorlitebamine Drug Info [534555]
N-isopropylnorlitebamineN-methoiodide Drug Info [534555]
N-Methyl-1'H-phenothiazine-1'-carboxamide Drug Info [530749]
N-n-dodecyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-n-heptyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-n-hexyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-n-nonyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-n-octyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-n-pentyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-n-propyl-7-methoxytacrine hydrochloride Drug Info [531150]
N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine Drug Info [530923]
N-propylnorlitebamine Drug Info [534555]
Neostigmine Drug Info [537124], [537383]
NP-61 Drug Info [525350]
NP-7557 Drug Info [547587]
NSC-23180 Drug Info [529103]
OBIDOXIME Drug Info [527865]
PARAOXON Drug Info [529440]
Petrosamine Drug Info [529521]
PHENSERINE TARTRATE Drug Info [527603], [551871]
Physostigmine Drug Info [533483]
Propidium Drug Info [551393]
PRX-105 Drug Info [533264]
Pseudocolumbamine trifluoroacetate Drug Info [551369]
Pseudopalmatine trifluoroacetate Drug Info [551369]
Pyridostigmine Drug Info [537124]
QUILOSTIGMINE Drug Info [531080]
R-phenserine Drug Info [527603]
Ro-46-5934 Drug Info [533753]
S-9977 Drug Info [526803]
SM-10888 Drug Info [532426]
SPH-1285 Drug Info [525994]
T-82 Drug Info [526578], [551871]
Tacrine Drug Info [535519]
TACRINE(8)-4-AMINOQUINOLINE Drug Info [551374]
TAK-802 Drug Info [526952]
TASPINE Drug Info [528444]
TERRITREM B Drug Info [551363]
Tetraethylene Glycol Drug Info [551393]
THIOCTIC ACID Drug Info [529250]
TOLSERINE Drug Info [531080]
TRIMEDOXIME Drug Info [527865]
Trimethyl-(3-nitro-phenyl)-ammonium iodide Drug Info [534296]
Trimethyl-(4-oxo-pentyl)-ammonium iodide Drug Info [534296]
TURBINATINE Drug Info [527312]
VELNACRINE Drug Info [551238]
VOACANGINE Drug Info [531166]
XANTHOSTIGMINE Drug Info [534716]
Zanapezil Drug Info [527590]
ZIFROSILONE Drug Info [533665], [551871]
ZT-1 Drug Info [527018], [551871]
Modulator ABS-301 Drug Info [534501]
CI-1002 Drug Info [533784]
CP-126998 Drug Info
Desoxypeganine Drug Info [529540]
Donepezil Drug Info [543634]
Echothiophate Iodide Drug Info [556264]
NPRx-30 Drug Info [543634]
Pralidoxime Chloride Drug Info [556264]
Rivastigmine Drug Info [543634]
Suronacrine maleate Drug Info
YM443 Drug Info [551871]
Activator MMB-4 Drug Info [543634]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 522744ClinicalTrials.gov (NCT00948766) Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44. U.S. National Institutes of Health.
Ref 522989ClinicalTrials.gov (NCT01093859) An Exploratory Phase 1 Microdose Study of PRX-105. U.S. National Institutes of Health.
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