Drug Information
Drug General Information | |||||
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Drug ID |
D0TK0W
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Former ID |
DIB010295
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Drug Name |
Ro-46-5934
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Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Terminated | [1] | ||
Company |
F Hoffmann-La Roche Ltd
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Structure |
Download2D MOL |
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Canonical SMILES |
C(=O)(Oc1c2c([C@@H]3[C@@H](N(CC3)CCC3CCCCC3)CC2)ccc1)N(<br />C)C
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CAS Number |
CAS 158182-74-2
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Target and Pathway | |||||
Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [1] | |
KEGG Pathway | Glycerophospholipid metabolism | ||||
Cholinergic synapse | |||||
PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
Nicotinic acetylcholine receptor signaling pathway | |||||
Pathway Interaction Database | ATF-2 transcription factor network | ||||
PathWhiz Pathway | Phospholipid Biosynthesis | ||||
WikiPathways | Monoamine Transport | ||||
Biogenic Amine Synthesis | |||||
Acetylcholine Synthesis | |||||
Integrated Pancreatic Cancer Pathway | |||||
References | |||||
REF 1 | A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8. | ||||
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