Drug Information

Drug General Information
Drug ID
D08XQI
Former ID
DNC010373
Drug Name
PARAOXON
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529659]
Structure
Download
2D MOL

3D MOL
Formula
C10H14NO6P
Canonical SMILES
CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI
1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
InChIKey
WYMSBXTXOHUIGT-UHFFFAOYSA-N
CAS Number
CAS 311-45-5
PubChem Compound ID
9395
SuperDrug ATC ID
S01EB10
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [531156]
Fatty-acid amide hydrolase Target Info Inhibitor [529440]
Carbonic anhydrase I Target Info Inhibitor [531156]
Cannabinoid receptor 1 Target Info Inhibitor [529659]
Acetylcholinesterase Target Info Inhibitor [529440]
Carbonic anhydrase II Target Info Inhibitor [531156]
BioCyc Pathway Anandamide degradation
KEGG Pathway Retrograde endocannabinoid signalinghsa00910:Nitrogen metabolismhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa00564:Glycerophospholipid metabolism
Cholinergic synapsehsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Anandamide degradationP05730:Endogenous cannabinoid signalingP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database C-MYB transcription factor networkncadherinpathway:N-cadherin signaling eventsatf2_pathway:ATF-2 transcription factor network
PathWhiz Pathway Gastric Acid ProductionPW000048:Phospholipid Biosynthesis
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP455:GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer PathwayWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Ref 529440Nat Chem Biol. 2008 Jun;4(6):373-8. Epub 2008 Apr 27.Activation of the endocannabinoid system by organophosphorus nerve agents.
Ref 529659Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Ref 531156Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases.

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