Drug General Information
Drug ID	D0C3UC
Former ID	DIB007180
Drug Name	Ladostigil
Synonyms	Ladostigil tartrate; Alzheimer disease therapeutics, Teva; TV-3219; TV-3279; TV-3326
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 2	[531772]
Company	Hebrew University of Jerusalem
Structure		Download 2D MOL 3D MOL
Formula	C16H20N2O2
Canonical SMILES	C(=O)(Oc1cc2c(CC[C@H]2NCC#C)cc1)N(CC)C
PubChem Compound ID	208907
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] B	Target Info	Inhibitor	[531772]
	Amine oxidase [flavin-containing] A	Target Info	Inhibitor	[531772]
	Acetylcholinesterase	Target Info	Inhibitor	[531772]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
	Noradrenaline and adrenaline degradation
	Serotonin degradation
	Superpathway of melatonin degradation
	Melatonin degradation II
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholismhsa00260:Glycine, serine and threonine metabolism
	Alcoholismhsa00564:Glycerophospholipid metabolism
	Cholinergic synapse
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	Dopamine receptor mediated signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	Alpha-synuclein signalingatf2_pathway:ATF-2 transcription factor network
PathWhiz Pathway	Histidine Metabolism
	Tyrosine Metabolism
	Glycine and Serine MetabolismPW000048:Phospholipid Biosynthesis
Reactome	Norepinephrine Neurotransmitter Release Cycle
WikiPathways	Tryptophan metabolism
	Dopamine metabolism
	Phase 1 - Functionalization of compoundsWP706:SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	Oxidative Stress
	Phase 1 - Functionalization of compounds
	Neurotransmitter Release Cycle
	Neurotransmitter Clearance In The Synaptic Cleft
	Serotonin Transporter ActivityWP727:Monoamine Transport
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 531772	Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
Ref 531772	Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.

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