Drug General Information
Drug ID	D0W6PT
Former ID	DNC014028
Drug Name	Chlorphrifos oxon
Synonyms	Diethyl 3,5,6-trichloropyridin-2-yl phosphate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529659]
Structure		Download 2D MOL 3D MOL
Formula	C9H11Cl3NO4P
Canonical SMILES	CCOP(=O)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl
InChI	1S/C9H11Cl3NO4P/c1-3-15-18(14,16-4-2)17-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
InChIKey	OTMOUPHCTWPNSL-UHFFFAOYSA-N
PubChem Compound ID	21804
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[529440]
	Fatty-acid amide hydrolase	Target Info	Inhibitor	[529440]
	Cannabinoid receptor 1	Target Info	Inhibitor	[529659]
BioCyc Pathway	Anandamide degradation
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapsehsa04723:Retrograde endocannabinoid signalinghsa04015:Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathwayP05728:Anandamide degradationP05730:Endogenous cannabinoid signaling
Pathway Interaction Database	ATF-2 transcription factor networkncadherinpathway:N-cadherin signaling events
PathWhiz Pathway	Phospholipid Biosynthesis
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer PathwayWP455:GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 529659	Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.
Ref 529440	Nat Chem Biol. 2008 Jun;4(6):373-8. Epub 2008 Apr 27.Activation of the endocannabinoid system by organophosphorus nerve agents.
Ref 529659	Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. Epub 2008 Aug 6.Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.

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