Drug General Information
Drug ID	D07EDG
Former ID	DNC007179
Drug Name	1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528749]
Structure		Download 2D MOL 3D MOL
Formula	C15H9Cl2NO2
Canonical SMILES	C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
InChI	1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChIKey	KGRJPLRFGLMQMV-UHFFFAOYSA-N
PubChem Compound ID	1901244
Target and Pathway
Target(s)	Cholinesterase	Target Info	Inhibitor	[528749]
	Liver carboxylesterase	Target Info	Inhibitor	[528749]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	E2F transcription factor network
WikiPathways	Irinotecan PathwayWP2884:NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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