Drug Information

Drug General Information
Drug ID
D07KYU
Former ID
DNC000293
Drug Name
Benactyzine
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Withdrawn from market [526766]
Structure
Download
2D MOL

3D MOL
Formula
C20H25NO3
Canonical SMILES
CCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O
InChI
1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3
InChIKey
IVQOFBKHQCTVQV-UHFFFAOYSA-N
CAS Number
CAS 302-40-9
PubChem Compound ID
9330
PubChem Substance ID
5589361, 8156673, 10517764, 15323332, 29215374, 29215375, 29227934, 48415604, 49882418, 51091823, 57325585, 76110435, 88826491, 95651880, 103267925, 104033594, 104320212, 115997952, 124892194, 126688208, 128227073, 134223988, 134339757, 134973255, 137131399, 144205218, 162224672, 169174904, 170466568, 179225185, 198987026, 223667229, 226432918, 241059525, 249950785
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Antagonist [537749]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 526766Benactyzine as an aid in treatment of anxiety states; preliminary report. Br Med J. 1957 Feb 9;1(5014):306-10.
Ref 537749The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.