Drug Information

Drug General Information
Drug ID
D07QFP
Former ID
DCL000314
Drug Name
Teriflunomide
Synonyms
Flucyamide; Active metabolite of leflunomide; Teriflunomide [INN]; A 771726; HMR 1726; RS 61980; SU 20; A-771726; HMR-1726; RS-61980; SU-0020; N-(4-Trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide; (2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxobutanenitrile; (Z)-2-Cyano-alpha'alpha'alpha-trifluoro-3-hydroxy-p-crotonotoluidide; 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide; 2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilide
Drug Type
Small molecular drug
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Approved [532210], [541924]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 3 [536604], [541924]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C12H9F3N2O2
InChI
InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
InChIKey
UTNUDOFZCWSZMS-YFHOEESVSA-N
CAS Number
CAS 163451-81-8
PubChem Compound ID
54684141
PubChem Substance ID
605680, 836841, 8020778, 12014666, 15221873, 17182873, 29223012, 32961983, 36887811, 39470329, 49896832, 53790606, 57363933, 77206778, 77206779, 77206780, 93311044, 99311205, 103252419, 103929187, 104304838, 104633246, 113986292, 131294182, 134223898, 134338701, 134338970, 134340294, 134340452, 135074184, 135263629, 135626890, 137116564, 143267135, 152134192, 160645856, 162254943, 163414519, 163620868, 163686197, 164178177, 164835947, 172919649, 175266318, 176251501, 178103450, 180100588, 180371831, 187072836, 198993049
SuperDrug ATC ID
L04AA31
Target and Pathway
Target(s) Dihydroorotate dehydrogenase Target Info Modulator [532210]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PANTHER Pathway De novo pyrimidine ribonucleotides biosythesis
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 536604Multiple sclerosis: current and future treatment options. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):292-9.
Ref 541924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6844).
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.

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