Target Information

Target General Infomation
Target ID
T61400
Former ID
TTDI00862
Target Name
Dihydroorotate dehydrogenase
Gene Name
DHODH
Synonyms
DHOdehase; Dihydroorotate dehydrogenase (quinone), mitochondrial; Dihydroorotate oxidase; DHODH
Target Type
Successful
Disease Kidney transplant rejection; Heart transplant rejection [ICD9: 996; ICD10: T86]
Multiple scierosis [ICD9: 340; ICD10: G35]
Rheumatold arthritis; Inflammatory bowel disease [ICD9: 555, 556, 710-719, 714; ICD10: K50, K51, M00-M25, M05-M06]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
BioChemical Class
Oxidoreductases acting on CH-CH group of donors
UniProt ID
Q02127
EC Number
EC 1.3.5.2
Sequence
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Drugs and Mode of Action
Drug(s) Teriflunomide Drug Info Approved Multiple scierosis [532210], [541924]
Teriflunomide Drug Info Phase 3 Rheumatoid arthritis [536604], [541924]
Vidofludimus Drug Info Phase 2 Rheumatold arthritis; Inflammatory bowel disease [551497]
LAS-186323 Drug Info Phase 1 Multiple scierosis [548790]
BREQUINAR Drug Info Discontinued in Phase 2 Discovery agent [542429], [544729]
FK778 Drug Info Discontinued in Phase 2 Kidney transplant rejection; Heart transplant rejection [537129]
HR325 Drug Info Discontinued in Phase 2 Rheumatoid arthritis [545844]
Modulator BREQUINAR Drug Info
FK778 Drug Info
HR325 Drug Info
Teriflunomide Drug Info [532210]
Vidofludimus Drug Info
Inhibitor LAS-186323 Drug Info [550281]
Pathways
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PANTHER Pathway De novo pyrimidine ribonucleotides biosythesis
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 536604Multiple sclerosis: current and future treatment options. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):292-9.
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 541924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6844).
Ref 542429(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7406).
Ref 544729Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000749)
Ref 545844Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005016)
Ref 548790Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028859)
Ref 5514972011 Pipeline of 4SC AG.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 550281Clinical pipeline report, company report or official report of Aslanpharma.

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