Drug General Information
Drug ID	D07RPB
Former ID	DIB006811
Drug Name	HT-90B
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Terminated	[545512]
Company	Chugai Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C12(C(=O)NCCNCC3Oc4c(OC3)cccc4C)CC3CC(C2)CC(C1)C3
CAS Number	CAS 150710-80-8
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Modulator	[534198]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545512	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003558)
Ref 534198	Pharmacological profile of (-)HT-90B, a novel 5-HT1A receptor agonist/5-HT2 receptor antagonist. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Nov;19(7):1201-16.

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