Target Information

Target General Infomation
Target ID
T78709
Former ID
TTDS00098
Target Name
5-hydroxytryptamine 1A receptor
Gene Name
HTR1A
Synonyms
5-HT-1A; 5-HT1A; 5-HT1A receptor; 5-hydroxytryptamine receptor 1A; G-21; Serotonin receptor; Serotonin receptor 1A; HTR1A
Target Type
Successful
Disease Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis [ICD9:331.0, 356.0, 356.8; ICD10: G30, G64, G90.0, G12.2]
Alzheimer disease [ICD9: 331; ICD10: G30]
Addiction [ICD code not available]
Aggressive non-hodgkin's lymphoma [ICD9: 200, 201, 202, 202.8, 208.9; ICD10: C81, C81-C86, C82-C85, C91-C95]
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Bulimia nervosa; Severe mood disorders [ICD9: 296, 307.51; ICD10: F30-F39, F50.2]
Coronary artery disease [ICD9: 410-414, 429.2; ICD10: I20-I25]
Cervical dystonia; Spasm [ICD9:333.83, 728.85; ICD10: G24.3, R25.2]
Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3]
Depression [ICD9: 311; ICD10: F30-F39]
Eating disorder [ICD9: 278, 307.5, 401, 428.0; ICD10: E66, F50, I10-I16, I50]
Female sexual dysfunction [ICD9: 302.7; ICD10: F52]
Generalized anxiety disorder [ICD9: 300, 300.02, 311; ICD10: F32, F40-F42, F41.1]
Generalized anxiety disorder; Social phobia [ICD9: 300, 300.02, 300.23; ICD10: F40-F42, F40.1, F41.1, F93.2]
Hypoactive sexual desire disorder [ICD10: F52.0]
Hypertension [ICD9: 401; ICD10: I10-I16]
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0]
Major depressive disorder; Episode; Anxiety [ICD9: 296.2, 296.3, 300; ICD10: F32, F32.2, F32.3, F33, F40-F42]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Mood disorder [ICD10: F30-F39]
Migraine [ICD9: 346; ICD10: G43]
Post-traumatic stress disorder [ICD9: 309.81; ICD10: F43.1]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Psychiatric disorder [ICD9: 290-319; ICD10: F01-F99]
Parkinson's disease [ICD9: 332; ICD10: G20]
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
Premature ejaculation [ICD9: 302.75; ICD10: F52.4]
Severe mood disorders [ICD9: 296; ICD10: F30-F39]
Schizoaffective disorder; Schizophrenia [ICD9: 295, 295.70; ICD10: F20, F25]
Schizophrenia [ICD9: 295; ICD10: F20]
Urinary incontinence [ICD9: 788.3; ICD10: N39.3, N39.4, R32]
Unspecified [ICD code not available]
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
BioChemical Class
GPCR rhodopsin
Target Validation
T78709
UniProt ID
P08908
Sequence
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
Drugs and Mode of Action
Drug(s) Buspirone Drug Info Approved Anxiety disorder [1], [2]
Flibanserin Drug Info Approved Mood disorder [3], [4]
OPC-34712 Drug Info Approved Major depressive disorder [5], [6]
TERTATOLOL Drug Info Approved Hypertension [7], [8]
Trazodone Drug Info Approved Depression [9], [10]
Treximet Drug Info Approved Migraine [11]
Urapidil Drug Info Approved Hypertension [8]
Vilazodone Drug Info Approved Major depressive disorder [12], [13]
CM-2395 Drug Info Phase 3 Schizophrenia [14]
Flibanserin Drug Info Phase 3 Female sexual dysfunction [15], [4]
LECOZOTAN HYDROCHLORIDE Drug Info Phase 2/3 Cognitive disorders [16]
Eltoprazine Drug Info Phase 2 Aggressive non-hodgkin's lymphoma [17]
Ensaculin hydrochloride Drug Info Phase 2 Parkinson's disease [18]
Mazapertine succinate Drug Info Phase 2 Psychotic disorders [19]
MIN-117 Drug Info Phase 2 Major depressive disorder [20]
MN-305 Drug Info Phase 2 Severe mood disorders [21]
Neu-P11 Drug Info Phase 2 Insomnia [22]
OPC-14523 Drug Info Phase 2 Bulimia nervosa; Severe mood disorders [15]
ORG-13011 Drug Info Phase 2 Psychotic disorders [23]
RP5063 Drug Info Phase 2 Schizoaffective disorder; Schizophrenia [24]
S-15535 Drug Info Phase 2 Anxiety disorder [25], [26]
S-16924 Drug Info Phase 2 Anxiety disorder [27], [28], [29]
SDZ-MAR-327 Drug Info Phase 2 Psychotic disorders [30], [31]
SUN N4057 Drug Info Phase 2 Coronary artery disease [32]
TGBA01AD Drug Info Phase 2 Severe mood disorders [21]
TGFK08AA-ER Drug Info Phase 2 Generalized anxiety disorder [33]
TGFK09SD-ER Drug Info Phase 2 Hypoactive sexual desire disorder [34]
TGWOOAA Drug Info Phase 2 Generalized anxiety disorder; Social phobia [35]
Zalospirone Drug Info Phase 2 Anxiety disorder [36], [37]
1192U90 Drug Info Phase 1 Psychotic disorders [38]
AV-965 Drug Info Phase 1 Alzheimer disease [39]
DSP-1053 Drug Info Phase 1 Major depressive disorder [40]
GSK-958108 Drug Info Phase 1 Premature ejaculation [41]
OPC-14523 Drug Info Phase 1 Female sexual dysfunction [15]
SSR-181507 Drug Info Phase 1 Schizophrenia [31]
Umespirone Drug Info Phase 1 Anxiety disorder [42]
CM-2236 Drug Info Preclinical Post-traumatic stress disorder [43]
PD-158771 Drug Info Preclinical Schizophrenia [31]
LYSERGIC ACID DIETHYLAMIDE Drug Info Withdrawn from market Addiction [44], [45]
Bifeprunox Drug Info Discontinued in Phase 3 Schizophrenia [31]
BMS-181100 Drug Info Discontinued in Phase 3 Psychotic disorders [46], [47]
Flesinoxan Drug Info Discontinued in Phase 3 Anxiety disorder [48], [49]
Sunepitron Drug Info Discontinued in Phase 3 Discovery agent [50]
TIOSPIRONE Drug Info Discontinued in Phase 3 Discovery agent [51], [52]
Xaliproden Drug Info Discontinued in Phase 3 Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis [53]
Adatanserin Drug Info Discontinued in Phase 2 Severe mood disorders [21]
ALNESPIRONE Drug Info Discontinued in Phase 2 Anxiety disorder [54]
AP-521 Drug Info Discontinued in Phase 2 Anxiety disorder [55]
DU 125530 Drug Info Discontinued in Phase 2 Mood disorder [56]
GSK163090 Drug Info Discontinued in Phase 2 Major depressive disorder; Episode; Anxiety [57]
LESOPITRON DIHYDROCHLORIDE Drug Info Discontinued in Phase 2 Mood disorder [58]
MAZAPERTINE Drug Info Discontinued in Phase 2 Discovery agent [59]
PRX-00023 Drug Info Discontinued in Phase 2 Severe mood disorders [21]
REC-15/3079 Drug Info Discontinued in Phase 2 Urinary incontinence [60], [61]
Robalzotan Drug Info Discontinued in Phase 2 Anxiety disorder [62], [63]
Sarizotan Drug Info Discontinued in Phase 2 Parkinson's disease [64]
BINOSPIRONE MESYLATE Drug Info Discontinued in Phase 1 Anxiety disorder [65]
DU-29894 Drug Info Discontinued in Phase 1 Psychotic disorders [66]
E2101 Drug Info Discontinued in Phase 1 Cervical dystonia; Spasm [67]
Ebalzotan Drug Info Discontinued in Phase 1 Anxiety disorder [68]
Eptapirone Drug Info Discontinued in Phase 1 Anxiety disorder [69]
GR-127607 Drug Info Discontinued in Phase 1 Migraine [70]
Nerisopam Drug Info Discontinued in Phase 1 Anxiety disorder [71]
SLV-313 Drug Info Discontinued in Phase 1 Schizophrenia [31]
SUN-8399 Drug Info Discontinued in Phase 1 Anxiety disorder [72]
U-93385 Drug Info Discontinued in Phase 1 Anxiety disorder [73]
1192U90 Drug Info Terminated Schizophrenia [31]
A-74283 Drug Info Terminated Hypertension [74]
A-80426 Drug Info Terminated Discovery agent [75]
Anpirtoline Drug Info Terminated Pain [76]
BMY-7378 Drug Info Terminated Discovery agent [77], [78]
BTS-79018 Drug Info Terminated Schizophrenia [31]
CGS-18102A Drug Info Terminated Anxiety disorder [79]
CP-293019 Drug Info Terminated Discovery agent [80], [81]
Du-123015 Drug Info Terminated Anxiety disorder [82]
Gepirone ER Drug Info Terminated Depression [21]
HT-90B Drug Info Terminated Anxiety disorder [83]
Ipsapirone Drug Info Terminated Anxiety disorder [84], [85]
LY-293284 Drug Info Terminated Anxiety disorder [86], [87]
NAN-190 Drug Info Terminated Discovery agent [88], [89]
RWJ-25730 Drug Info Terminated Psychotic disorders [90]
S-14506 Drug Info Terminated Anxiety disorder [91], [92]
SDZ 216-525 Drug Info Terminated Discovery agent [93], [94]
SDZ-MAR-327 Drug Info Terminated Schizophrenia [31]
SLV-307 Drug Info Terminated Parkinson's disease [95]
WAY 100135 Drug Info Terminated Discovery agent [96], [97]
WAY-100635 Drug Info Terminated Eating disorder [98], [99]
WB-4101 Drug Info Terminated Discovery agent [100], [101]
Sunepitron Drug Info Investigative Unspecified [102]
Inhibitor (3-Chloro-phenyl)-piperazin-1-yl-methanone Drug Info [103]
(R)-(-)-10-methyl-11-hydroxyaporphine Drug Info [104]
(R)-11-Amino-2-methoxyaporphine Drug Info [105]
(R)-2,11-Diaminoaporphine Drug Info [105]
1,2,3,4-Tetrahydro-naphthalen-2-ylamine Drug Info [106]
1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane Drug Info [107]
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane Drug Info [107]
1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane Drug Info [107]
1,6-bis(4-m-tolylpiperazin-1-yl)hexane Drug Info [107]
1,6-bis(4-phenylpiperazin-1-yl)hexane Drug Info [107]
1-((S)-2-aminopropyl)-1H-indazol-6-ol Drug Info [108]
1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine Drug Info [103]
1-(2,5-Dimethoxy-phenyl)-piperazine Drug Info [103]
1-(2,5-dimethoxyphenyl)propan-2-amine Drug Info [109]
1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine Drug Info [110]
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine Drug Info [111]
1-(2-(2-fluorobenzyloxy)phenyl)piperazine Drug Info [110]
1-(2-(3-fluorophenoxy)phenyl)piperazine Drug Info [110]
1-(2-(4-fluorophenoxy)phenyl)piperazine Drug Info [110]
1-(2-(benzyloxy)phenyl)piperazine Drug Info [110]
1-(2-(phenoxymethyl)phenyl)piperazine Drug Info [110]
1-(2-Butoxy-phenyl)-piperazine Drug Info [112]
1-(2-Chloro-phenyl)-piperazine Drug Info [113]
1-(2-Ethoxy-phenyl)-piperazine Drug Info [112]
1-(2-Fluoro-phenyl)-piperazine Drug Info [112]
1-(2-Isopropoxy-phenyl)-piperazine Drug Info [112]
1-(2-Methoxy-phenyl)-4-propyl-piperazine Drug Info [114]
1-(2-Methoxy-phenyl)-piperazine Drug Info [113]
1-(2-methoxyphenyl)-4-pentylpiperazine Drug Info [115]
1-(2-phenoxyphenyl)piperazine Drug Info [110]
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine Drug Info [116]
1-(3-Fluoro-phenyl)-piperazine Drug Info [112]
1-(3-Nitro-phenyl)-piperazine Drug Info [112]
1-(3-Trifluoromethyl-phenyl)-piperazine Drug Info [103]
1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine Drug Info [103]
1-(7-Methoxy-naphthalen-2-yl)-piperazine Drug Info [117]
1-(benzyloxy)-2-(2-phenylethyl)benzene Drug Info [118]
1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene Drug Info [118]
1-Benzyl-4-chroman-2-ylmethyl-piperazine Drug Info [119]
1-Butyl-4-(2-methoxy-phenyl)-piperazine Drug Info [114]
1-Ethyl-4-(2-methoxy-phenyl)-piperazine Drug Info [114]
1-Methyl-1,3-dihydro-indol-2-one Drug Info [120]
1-Naphthalen-1-yl-piperazine Drug Info [106]
1-Naphthalen-2-yl-piperazine Drug Info [106]
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine Drug Info [121]
1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene Drug Info [118]
2-(2'-methyl-biphenyl-3-yl)-ethylamine Drug Info [122]
2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol Drug Info [109]
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info [111]
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info [111]
2-(2-Methoxy-phenyl)-1-methyl-ethylamine Drug Info [109]
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine Drug Info [111]
2-(3-Bromophenylthio)-N,N-dimethylethanamine Drug Info [123]
2-(3-Methoxy-phenyl)-1-methyl-ethylamine Drug Info [109]
2-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one Drug Info [119]
2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine Drug Info [109]
2-(4-Bromo-phenyl)-1-methyl-ethylamine Drug Info [109]
2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine Drug Info [124]
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine Drug Info [125]
2-(Biphenyl-3-ylthio)-N,N-dimethylethanamine Drug Info [123]
2-Dipropylamino-1,2,3,4-tetrahydro-anthracen-9-ol Drug Info [126]
2-phenoxy-3-(piperidin-4-yl)pyridine Drug Info [111]
2-Piperazin-1-yl-benzonitrile Drug Info [112]
2-Piperazin-1-yl-phenol Drug Info [103]
2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Drug Info [118]
3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole Drug Info [127]
3-(1-Propyl-pyrrolidin-3-yl)-phenol Drug Info [121]
3-(2-Amino-propyl)-1H-indol-5-ol Drug Info [125]
3-(2-Benzylamino-ethoxy)-phenol Drug Info [128]
3-(3-Methanesulfonyl-phenyl)-1-propyl-pyrrolidine Drug Info [121]
3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one Drug Info [119]
3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one Drug Info [119]
3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine Drug Info [111]
3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one Drug Info [103]
3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol Drug Info [129]
3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol Drug Info [129]
3-Naphthalen-1-yl-1-propyl-pyrrolidine Drug Info [121]
3-Naphthalen-1-yl-pyrrolidine Drug Info [121]
3-Phenyl-1-propyl-pyrrolidine Drug Info [121]
3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Drug Info [118]
4-(1H-indol-4-yloxy)-1-(isopropylamino)butan-2-ol Drug Info [130]
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine Drug Info [110]
4-(2-(2-fluorobenzyloxy)phenyl)piperidine Drug Info [110]
4-(2-(3-chlorophenoxy)phenyl)piperidine Drug Info [110]
4-(2-(3-fluorophenoxy)phenyl)piperidine Drug Info [110]
4-(2-(4-fluorobenzyloxy)phenyl)piperidine Drug Info [110]
4-(2-(4-fluorophenoxy)phenyl)piperidine Drug Info [110]
4-(2-(benzyloxy)-3-fluorophenyl)piperidine Drug Info [110]
4-(2-(benzyloxy)-6-fluorophenyl)piperidine Drug Info [110]
4-(2-(benzyloxy)phenyl)piperidine Drug Info [110]
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine Drug Info [111]
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine Drug Info [110]
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine Drug Info [110]
4-(2-fluoro-6-phenoxyphenyl)piperidine Drug Info [110]
4-(2-phenoxyphenyl)piperidine Drug Info [110]
4-(3-fluoro-2-phenoxyphenyl)piperidine Drug Info [110]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [131]
4-Benzyl-1-chroman-2-ylmethyl-piperidine Drug Info [119]
4-Benzyl-1-chroman-3-ylmethyl-piperidine Drug Info [119]
5,6-dichloro-3,4-dihydroquinazolin-2-amine Drug Info [132]
5-chloro-3,4-dihydroquinazolin-2-amine Drug Info [132]
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine Drug Info [132]
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info [132]
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine Drug Info [126]
8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline Drug Info [106]
8-Methoxy-2-piperazin-1-yl-quinoline Drug Info [106]
8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info [132]
8-Methoxy-quinolin-2-ylamine Drug Info [106]
9-Methoxy-1,2,3,4-tetrahydro-anthracen-2-ylamine Drug Info [126]
A-80426 Drug Info [133]
A-987306 Drug Info [134]
AGROCLAVINE Drug Info [135]
BMY-7378 Drug Info [136]
Brolamfetamine Drug Info [109]
CHLOROPHENYLPIPERAZINE Drug Info [112]
CP-293019 Drug Info [137]
ESCHOLTZINE Drug Info [138]
Etisulergine Drug Info [139]
JNJ-10392980 Drug Info [140]
LYSERGIC ACID DIETHYLAMIDE Drug Info [141]
MAZAPERTINE Drug Info [142]
MCL-516 Drug Info [105]
N-(3-(1H-indol-4-yloxy)propyl)cyclohexanamine Drug Info [130]
N-(3-(1H-indol-4-yloxy)propyl)cyclopentanamine Drug Info [130]
N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide Drug Info [143]
N-methyllaurotetanine Drug Info [138]
N-[4-(4-Phenyl-piperazin-1-yl)-butyl]-benzamide Drug Info [144]
PB-28 Drug Info [145]
PG-01037 Drug Info [146]
PHENYLPIPERAZINE Drug Info [106]
QUIPAZINE Drug Info [147]
SB-271046 Drug Info [148]
SB-656104 Drug Info [149]
SEROTONIN Drug Info [147]
SNAP-8719 Drug Info [150]
SPIPERONE Drug Info [151]
Sunepitron Drug Info [102]
TERTATOLOL Drug Info [126]
TIOSPIRONE Drug Info [152]
UH-232 Drug Info [153]
UH-301 Drug Info [154]
WAY-466 Drug Info [155]
WB-4101 Drug Info [151]
Antagonist (R)-flurocarazolol Drug Info [156]
(S)-flurocarazolol Drug Info [156]
(S)-UH-301 Drug Info [157]
(S)-WAY 100135 Drug Info [157]
9-OH-risperidone Drug Info [158]
AV-965 Drug Info [159]
BINOSPIRONE MESYLATE Drug Info [160], [8]
cyamemazine Drug Info [161]
DSP-1053 Drug Info [162]
DU 125530 Drug Info [163]
GR 125,743 Drug Info [164]
GSK-958108 Drug Info [165]
GSK163090 Drug Info [166]
LECOZOTAN HYDROCHLORIDE Drug Info [167], [8]
LY433221 Drug Info [168]
MIN-117 Drug Info [169]
MPDT Drug Info [170]
NAN-190 Drug Info [157]
ORG-13011 Drug Info [171], [8]
P-MPPI Drug Info [157], [172]
p-[18F]MPPF Drug Info [173]
PD-158771 Drug Info [31]
REC-15/3079 Drug Info [174]
repinotan Drug Info [175]
Robalzotan Drug Info [176]
RP5063 Drug Info [177], [178]
S-15535 Drug Info [179], [8]
SB 272183 Drug Info [180]
SB 649915 Drug Info [181]
SB 714786 Drug Info [181]
SDZ 216-525 Drug Info [157]
SLV-307 Drug Info [182]
TGWOOAA Drug Info [183]
Treximet Drug Info [166]
Umespirone Drug Info [184]
WAY 100135 Drug Info [157]
WAY-100635 Drug Info [185], [186], [163]
Xaliproden Drug Info [187]
[11C]WAY100635 Drug Info [188]
[3H]p-MPPF Drug Info [189]
[3H]robalzotan Drug Info [190]
[3H]WAY100635 Drug Info [191]
Agonist 1-naphthylpiperazine Drug Info [117]
1192U90 Drug Info [31]
5-CT Drug Info [164]
7-methoxy-1-naphthylpiperazine Drug Info [117]
A-74283 Drug Info [192]
Adatanserin Drug Info [193], [21]
ALNESPIRONE Drug Info [194], [8]
AP-521 Drug Info [195], [8]
BRL-15572 Drug Info [196]
Buspirone Drug Info [197]
CM-2236 Drug Info [198]
CM-2395 Drug Info [199]
CP 93129 Drug Info [164]
Dual norepinephrine reuptake inhibitors/5-HT1A partial agonists Drug Info [200]
Ebalzotan Drug Info [201]
Eltoprazine Drug Info [202]
EMDT Drug Info [170]
Eptapirone Drug Info [203]
FG-5893 Drug Info [204]
Flesinoxan Drug Info [205]
Gepirone ER Drug Info [21]
GR-127607 Drug Info [206]
Ipsapirone Drug Info [207]
L-772,405 Drug Info [208]
LESOPITRON DIHYDROCHLORIDE Drug Info [209]
LP-12 Drug Info [210]
LP-211 Drug Info [143]
LP-44 Drug Info [210]
LY 165,163 Drug Info [204]
LY-293284 Drug Info [211]
MN-305 Drug Info [21]
nafadotride Drug Info [204]
Nerisopam Drug Info [212]
Neu-P11 Drug Info [213]
piribedil Drug Info [214]
S-14671 Drug Info [215]
SB 216641 Drug Info [196]
spiroxatrine Drug Info [204]
SUN N4057 Drug Info [216]
SUN-8399 Drug Info [217]
U-93385 Drug Info [218], [8]
U92016A Drug Info [219]
Urapidil Drug Info [220]
Zalospirone Drug Info [36]
[3H]8-OH-DPAT Drug Info [221]
[3H]NLX-112 Drug Info [222]
[3H]S-15535 Drug Info [215]
Modulator Anpirtoline Drug Info [76]
Bifeprunox Drug Info
BMS-181100 Drug Info
CGS-18102A Drug Info [223]
CGS-19480A Drug Info [224], [8]
Du-123015 Drug Info [225]
DU-29894 Drug Info [226]
E2101 Drug Info [227]
EMD 56551 Drug Info
Ensaculin hydrochloride Drug Info [18]
Flibanserin Drug Info [3]
HT-90B Drug Info [228]
Mazapertine succinate Drug Info
NLX-101 Drug Info
NPT-500 Drug Info [200]
OPC-14523 Drug Info [229]
OPC-34712 Drug Info
PRX-00023 Drug Info
RWJ-25730 Drug Info
S-14506 Drug Info
S-16924 Drug Info [27], [28]
Sarizotan Drug Info
SDZ-MAR-327 Drug Info
SEL-73 Drug Info [200]
SKL-PSY Drug Info [200]
SLV-313 Drug Info
SR-59026 Drug Info
SSR-181507 Drug Info
TGBA01AD Drug Info
TGFK08AA-ER Drug Info [230]
TGFK09SD-ER Drug Info [231]
Trazodone Drug Info [232]
Vilazodone Drug Info [12]
Binder BTS-79018 Drug Info [31]
Modulator (allosteric modulator) RS-30199 Drug Info [233]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
REF 1Glutamate and anxiety disorders. Curr Psychiatry Rep. 2007 Aug;9(4):278-83.
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