Drug Information

Drug General Information
Drug ID
D02OOL
Former ID
DIB019814
Drug Name
EMDT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538711]
Structure
Download
2D MOL
Formula
C15H22N2O
InChI
InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
InChIKey
ZEYRDXUWJDGTLD-UHFFFAOYSA-N
PubChem Compound ID
6918513
PubChem Substance ID
15196611, 23950832, 43529883, 47583774, 48029700, 80394596, 85301150, 99381476, 103165506, 114788091, 129892993, 134345310, 135650228, 137174577, 140775885, 144240229, 162221564, 228639384
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [525722]
5-hydroxytryptamine 1A receptor Target Info Agonist [525722]
5-hydroxytryptamine 6 receptor Target Info Agonist [525722]
5-hydroxytryptamine 7 receptor Target Info Agonist [525722]
5-hydroxytryptamine 5A receptor Target Info Agonist [525722]
5-hydroxytryptamine 1E receptor Target Info Agonist [525722]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Serotonergic synapsehsa04014:Ras signaling pathway
Calcium signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
References
Ref 538711(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 12).
Ref 5257222-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8.

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