Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R8GR
|
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| Former ID |
DCL000907
|
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| Drug Name |
OPC-14523
|
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| Drug Type |
Small molecular drug
|
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| Indication | Bulimia nervosa; Severe mood disorders [ICD9: 296, 307.51; ICD10:F30-F39, F50.2] | Phase 2 | [1] | ||
| Female sexual dysfunction [ICD9: 302.7; ICD10:F52] | Phase 1 | [1] | |||
| Company |
Otsuka Pharmaceutical and Vela Pharmaceuticals; Pharmos and Otsaku
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H28ClN3O2
|
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| Canonical SMILES |
COC1=CC=CC2=C1CCC(=O)N2CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
|
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| InChI |
1S/C23H28ClN3O2/c1-29-22-8-3-7-21-20(22)9-10-23(28)27(21)12-4-11-25-13-15-26(16-14-25)19-6-2-5-18(24)17-19/h2-3,5-8,17H,4,9-16H2,1H3
|
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| InChIKey |
TZZGTNZBLPCBIS-UHFFFAOYSA-N
|
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| CAS Number |
CAS 145969-30-8
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Sigma(1)-type opioid receptor | Target Info | Modulator | [2] | |
| 5-hydroxytryptamine 1A receptor | Target Info | Modulator | [2] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | miR-targeted genes in squamous cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBaseWP722:Serotonin HTR1 Group and FOS Pathway | |||||
| SIDS Susceptibility Pathways | |||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. Epub 2007 Aug 27. | ||||
| REF 2 | Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88. | ||||
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