Drug Information

Drug General Information
Drug ID
D0QM3E
Former ID
DIB020906
Drug Name
SB 272183
Synonyms
SB-272183
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542519]
Structure
Download
2D MOL
Formula
C29H28ClN5O
InChI
InChI=1S/C29H28ClN5O/c1-33-14-16-34(17-15-33)28-19-27-21(18-25(28)30)10-13-35(27)29(36)32-26-7-6-22(20-8-11-31-12-9-20)23-4-2-3-5-24(23)26/h2-9,11-12,18-19H,10,13-17H2,1H3,(H,32,36)
InChIKey
DAPBIPAGJXKFCI-UHFFFAOYSA-N
PubChem Compound ID
9870500
PubChem Substance ID
14835508, 24161347, 45292761, 77212956, 85224761, 103463705, 127706830, 135651002, 163359459, 233659231
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [526100]
5-hydroxytryptamine 1D receptor Target Info Antagonist [526100]
5-hydroxytryptamine 1A receptor Target Info Antagonist [526100]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signaling
References
Ref 542519(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 75).
Ref 526100SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol. 2001 Jul;133(6):797-806.

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